ARHGEF2

Gene Symbol	ARHGEF2
Entrez Gene	9181
Alt Symbol	GEF, GEF-H1, GEFH1, LFP40, P40
Species	Human
Gene Type	protein-coding
Description	Rho/Rac guanine nucleotide exchange factor (GEF) 2
Other Description	Rho/Rac guanine nucleotide exchange factor 2|guanine nucleotide exchange factor H1|microtubule-regulated Rho-GEF|proliferating cell nucleolar antigen p40|rho guanine nucleotide exchange factor 2
Swissprots	Q8WUG4 O75142 Q15079 D3DVA6 Q5VY92 Q9H023 Q92974 Q8TDA3
Accessions	EAW53012 EAW53013 EAW53014 EAW53015 EAW53016 EAW53017 EAW53018 Q92974 AB014551 BAA31626 AF486838 AAL96658 AI925929 AK127366 AK295924 BAG58711 AK304548 BAH14213 AL512715 CAC21656 AL832538 AM393305 CAL38183 BC020567 AAH20567 BC027722 BT007407 AAP36075 CN264153 CN388788 DQ891489 ABM82415 DQ894678 ABM85604 U72206 AAC97383 X15610 CAA33634 XM_005245587 XP_005245644 XM_005245588 XP_005245645 XM_005245589 XP_005245646 XM_005245590 XP_005245647 XM_005245591 XP_005245648 XM_005245592 XP_005245649 XM_005245593 XP_005245650 XM_005245594 XP_005245651 XM_006711622 XP_006711685 XM_006711623 XP_006711686 XM_006711624 XP_006711687 XM_006711625 XP_006711688 XM_006711626 XP_006711689 XM_011510136 XP_011508438 XM_011510137 XP_011508439 XM_011510138 XP_011508440 XM_011510139 XP_011508441 XM_011510140 XP_011508442 XM_011510141 XP_011508443 XM_011510142 XP_011508444 XM_011510143 XP_011508445 NM_001162383 NP_001155855 NM_001162384 NP_001155856 NM_004723 NP_004714
Function	Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF
Subcellular Location	Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cell projection, ruffle membrane. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton.
Top Pathways	Pathogenic Escherichia coli infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GEF H1 protein (His-DHFR tag) - ab127850 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

ARHGEF2 / GEF-H1 Antibody Blocking Peptide - LS-E21828 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GEF-H1 Protein - H00009181-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human GEF-H1 Protein - H00009181-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human GEF-H1 Protein - H00009181-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ARHGEF2 Blocking Peptide - 33R-6906 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ARHGEF2 - H00009181-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

ARHGEF2 - H00009181-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ARHGEF2 - H00009181-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ARHGEF2 - H00009181-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ARHGEF2 - H00009181-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ARHGEF2 - H00009181-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GEF-H1 fusion protein - ag13352 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

GEF-H1 fusion protein - ag13378 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GEF H1 Blocking Peptide - CBP2367 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ARHGEF2 (P881) Peptide - AP0469P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

ARHGEF2 (P881) Peptide - BS2442P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

ARHGEF2 Peptide - BS5781P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Rho guanine nucleotide exchange factor 2(ARHGEF2) ,partial - CSB-YP838822HU CSB-EP838822HU CSB-BP838822HU CSB-MP838822HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GEF H1 Blocking Peptide - abx161779 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Pig

ARHGEF2 - TP304546 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GEF-H1 Protein - NBP1-89777PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ARHGEF2 Peptide, Human - M34GP00888H from Creative Peptides Category Peptide Source Synthetic. Species Human

GEF H1 Blocking Peptide - CBP4568 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Pig

GEF-H1 Recombinant Protein Antigen - NBP2-58647PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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