| Gene Symbol | ARHGEF2 |
|---|---|
| Entrez Gene | 9181 |
| Alt Symbol | GEF, GEF-H1, GEFH1, LFP40, P40 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho/Rac guanine nucleotide exchange factor (GEF) 2 |
| Other Description | Rho/Rac guanine nucleotide exchange factor 2|guanine nucleotide exchange factor H1|microtubule-regulated Rho-GEF|proliferating cell nucleolar antigen p40|rho guanine nucleotide exchange factor 2 |
| Swissprots | Q8WUG4 O75142 Q15079 D3DVA6 Q5VY92 Q9H023 Q92974 Q8TDA3 |
| Accessions | EAW53012 EAW53013 EAW53014 EAW53015 EAW53016 EAW53017 EAW53018 Q92974 AB014551 BAA31626 AF486838 AAL96658 AI925929 AK127366 AK295924 BAG58711 AK304548 BAH14213 AL512715 CAC21656 AL832538 AM393305 CAL38183 BC020567 AAH20567 BC027722 BT007407 AAP36075 CN264153 CN388788 DQ891489 ABM82415 DQ894678 ABM85604 U72206 AAC97383 X15610 CAA33634 XM_005245587 XP_005245644 XM_005245588 XP_005245645 XM_005245589 XP_005245646 XM_005245590 XP_005245647 XM_005245591 XP_005245648 XM_005245592 XP_005245649 XM_005245593 XP_005245650 XM_005245594 XP_005245651 XM_006711622 XP_006711685 XM_006711623 XP_006711686 XM_006711624 XP_006711687 XM_006711625 XP_006711688 XM_006711626 XP_006711689 XM_011510136 XP_011508438 XM_011510137 XP_011508439 XM_011510138 XP_011508440 XM_011510139 XP_011508441 XM_011510140 XP_011508442 XM_011510141 XP_011508443 XM_011510142 XP_011508444 XM_011510143 XP_011508445 NM_001162383 NP_001155855 NM_001162384 NP_001155856 NM_004723 NP_004714 |
| Function | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF |
| Subcellular Location | Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cell projection, ruffle membrane. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton. |
| Top Pathways | Pathogenic Escherichia coli infection |
Lfc CRISPR/Cas9 KO Plasmid (h) - sc-405764 from Santa Cruz Biotechnology
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Lfc HDR Plasmid (h) - sc-405764-HDR from Santa Cruz Biotechnology
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Lfc Double Nickase Plasmid (h) - sc-405764-NIC from Santa Cruz Biotechnology
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Lfc Double Nickase Plasmid (h2) - sc-405764-NIC-2 from Santa Cruz Biotechnology
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Lfc CRISPR Activation Plasmid (h) - sc-405764-ACT from Santa Cruz Biotechnology
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Lfc CRISPR Activation Plasmid (h2) - sc-405764-ACT-2 from Santa Cruz Biotechnology
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Lfc Lentiviral Activation Particles (h) - sc-405764-LAC from Santa Cruz Biotechnology
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Lfc Lentiviral Activation Particles (h2) - sc-405764-LAC-2 from Santa Cruz Biotechnology
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Lfc siRNA (h) - sc-41723 from Santa Cruz Biotechnology
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Lfc shRNA Plasmid (h) - sc-41723-SH from Santa Cruz Biotechnology
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Lfc shRNA (h) Lentiviral Particles - sc-41723-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3451 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08231 from Sigma-Aldrich
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ARHGEF2 siRNA (Human) - CRH6075 from Cohesion Biosciences
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GEF-H1 RNAi - H00009181-R01 from Novus Biologicals
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ARHGEF2 - MBS8202553 from MyBioSource
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shRNA set against Human ARHGEF2 (NM_004723.3) - SHH239782 from Creative biogene
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Human ARHGEF2 siRNA - orb266577 from Biorbyt
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ARHGEF2 shRNA Plasmid (Human) - CHH6075 from Cohesion Biosciences
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ARHGEF2 miRNA 3'UTR clone - MiUTR3H-09308 from Creative biogene
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ARHGEF2 miRNA 3'UTR clone - MiUTR3H-09309 from Creative biogene
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ARHGEF2 miRNA 3'UTR clone - MiUTR3H-09310 from Creative biogene
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