| Gene Symbol |
VDAC2
|
| Entrez Gene |
7417
|
| Alt Symbol |
POR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
voltage-dependent anion channel 2
|
| Other Description |
outer mitochondrial membrane protein porin 2|voltage-dependent anion-selective channel protein 2
|
| Swissprots |
Q5VWK1 Q7L3J5 Q9Y5I6 Q9BWK8 P45880 Q6IB40 Q5VWK3
|
| Accessions |
AAD40241 EAW54569 EAW54570 EAW54571 EAW54572 EAW54573 EAW54574 P45880 AK296635 BAG59237 AK315919 BAH14290 BC000165 AAH00165 BC012883 AAH12883 BC072407 AAH72407 BE545584 BU171142 CF122447 CR456964 CAG33245 DA608755 DQ890934 ABM81860 DQ894097 ABM85023 L06328 AAB59457 L08666 AAA60144 XM_006717961 XP_006718024 XM_011540128 XP_011538430 NM_001184783 NP_001171712 NM_001184823 NP_001171752 NM_003375 NP_003366 NR_033675
|
| Function |
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:7539795}.
|
| Tissue Specificity |
Expressed in all tissues examined.
|
| Top Pathways |
Huntington's disease, Calcium signaling pathway, HTLV-I infection, cGMP-PKG signaling pathway
|