TOP1MT

Gene Symbol TOP1MT
Entrez Gene 116447
Alt Symbol -
Species Human
Gene Type protein-coding
Description topoisomerase (DNA) I, mitochondrial
Other Description DNA topoisomerase I, mitochondrial|mitochondrial topoisomerase IB
Swissprots Q969P6 Q86ST4 E7ES89 Q86V82 B7ZAR5
Accessions AAL10791 ADP90414 ADP90415 ADP90416 ADP90417 ADP90418 ADP90419 ADP90420 ADP90421 ADP90422 ADP90423 ADP90424 ADP90425 ADP90426 ADP90427 ADP90428 ADP90429 ADP90430 ADP90431 ADP90432 ADP90433 ADP90434 ADP90435 ADP90436 ADP90437 ADP90438 ADP90439 ADP90440 ADP90441 ADP90442 ADP90443 ADP90444 ADP90445 ADP90446 ADP90447 ADP90448 ADP90449 ADP90450 ADP90451 ADP90452 ADP90453 EAW82259 EAW82260 EAW82261 EAW82262 EAW82263 EAW82264 EAW82265 EAW82266 Q969P6 AF349017 AAL05624 AK302372 BAG63694 AK303237 BAG64323 AK308475 AK309005 AK311647 AK315913 BAH14284 AK316380 BAH14751 AW248607 BC027453 AAH27453 BC039358 BC044646 AAH44646 BC052285 AAH52285 BC071914 AAH71914 CB149603 DC375680 DC399840 XM_005250781 XP_005250838 NM_001258446 NP_001245375 NM_001258447 NP_001245376 NM_052963 NP_443195
Function Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:11526219}.
Tissue Specificity Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver. {ECO:0000269|PubMed:11526219}.

Mitochondrial Topo I (E-13) - sc-98014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Mitochondrial Topo I (N-14) - sc-98016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Mitochondrial Topo I (S-18) - sc-387039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TOP1MT antibody - ab121145 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121145 at 1/100 dilution staining TOP1MT in Paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry, showing strong nuclear and cytoplasmic positivity in neuronal cells. .

Anti-TOP1MT antibody - ab121681 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121681 at 1/175 dilution staining TOP1MT in Paraffin-embedded Human Colon tissue by Immunohistochemistry

Anti-TOP1MT antibody - C-terminal - ab135423 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TOP1MT antibody - C-terminal (ab135423) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-TOP1MT Antibody (aa522-571) - LS-C152187 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TOP1MT antibody Western Blot of HepG2.

TOP1MT Antibody - NBP1-86018 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TOP1MT Antibody [NBP1-86018] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

TOP1MT Antibody - NBP1-89473 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TOP1MT Antibody [NBP1-89473] - Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.

Rabbit Anti-TOP1mt/TOPO â  Polyclonal Antibody - bs-1211R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat heart labeled with Anti-TOP1mt/TOPO Ⅰ Polyclonal Antibody, Unconjugated (bs-1211R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Anti-TOP1MT antibody produced in rabbit - HPA001915 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TOP1MT: <B>Cat. No. HPA001915</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebellum tissue showing nuclear as well as cytoplasmic positivity in Purkinje cells and of cells in granular and molecular layer.

Anti-TOP1MT antibody produced in rabbit - HPA021542 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TOP1MT: <B>Cat. No. HPA021542</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

TOP1MT Antibody - C-terminal region (ARP66489_P050) - ARP66489_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Topoisomerase I antibody - orb11498 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin embedded rat heart tissue (dilution at:1:200) using Topoisomerase I antibody
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