| Gene Symbol |
TOP1MT
|
| Entrez Gene |
116447
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
topoisomerase (DNA) I, mitochondrial
|
| Other Description |
DNA topoisomerase I, mitochondrial|mitochondrial topoisomerase IB
|
| Swissprots |
Q969P6 Q86ST4 E7ES89 Q86V82 B7ZAR5
|
| Accessions |
AAL10791 ADP90414 ADP90415 ADP90416 ADP90417 ADP90418 ADP90419 ADP90420 ADP90421 ADP90422 ADP90423 ADP90424 ADP90425 ADP90426 ADP90427 ADP90428 ADP90429 ADP90430 ADP90431 ADP90432 ADP90433 ADP90434 ADP90435 ADP90436 ADP90437 ADP90438 ADP90439 ADP90440 ADP90441 ADP90442 ADP90443 ADP90444 ADP90445 ADP90446 ADP90447 ADP90448 ADP90449 ADP90450 ADP90451 ADP90452 ADP90453 EAW82259 EAW82260 EAW82261 EAW82262 EAW82263 EAW82264 EAW82265 EAW82266 Q969P6 AF349017 AAL05624 AK302372 BAG63694 AK303237 BAG64323 AK308475 AK309005 AK311647 AK315913 BAH14284 AK316380 BAH14751 AW248607 BC027453 AAH27453 BC039358 BC044646 AAH44646 BC052285 AAH52285 BC071914 AAH71914 CB149603 DC375680 DC399840 XM_005250781 XP_005250838 NM_001258446 NP_001245375 NM_001258447 NP_001245376 NM_052963 NP_443195
|
| Function |
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:11526219}.
|
| Tissue Specificity |
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver. {ECO:0000269|PubMed:11526219}.
|