| Gene Symbol |
MRGBP
|
| Entrez Gene |
55257
|
| Alt Symbol |
C20orf20, Eaf7, MRG15BP, URCC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MRG/MORF4L binding protein
|
| Other Description |
MRG(MORF4-related gene)-binding protein|MRG-binding protein|MRG/MORF4L-binding protein|up-regulated in colon cancer 4
|
| Swissprots |
Q9NV56 A8C4L5
|
| Accessions |
CAL23011 EAW75342 EAW75343 Q9NV56 AB085682 BAF80630 AK001776 BAA91902 BC009889 AAH09889 BC014235 AAH14235 BC018841 AAH18841 JF432751 ADZ15968 NM_018270 NP_060740
|
| Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
|
| Subcellular Location |
Nucleus.
|