Gene Symbol | MRGBP |
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Entrez Gene | 55257 |
Alt Symbol | C20orf20, Eaf7, MRG15BP, URCC4 |
Species | Human |
Gene Type | protein-coding |
Description | MRG/MORF4L binding protein |
Other Description | MRG(MORF4-related gene)-binding protein|MRG-binding protein|MRG/MORF4L-binding protein|up-regulated in colon cancer 4 |
Swissprots | Q9NV56 A8C4L5 |
Accessions | CAL23011 EAW75342 EAW75343 Q9NV56 AB085682 BAF80630 AK001776 BAA91902 BC009889 AAH09889 BC014235 AAH14235 BC018841 AAH18841 JF432751 ADZ15968 NM_018270 NP_060740 |
Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
Subcellular Location | Nucleus. |
MRGBP CRISPR/Cas9 KO Plasmid (h) - sc-412497 from Santa Cruz Biotechnology
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MRGBP HDR Plasmid (h) - sc-412497-HDR from Santa Cruz Biotechnology
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MRGBP Double Nickase Plasmid (h) - sc-412497-NIC from Santa Cruz Biotechnology
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MRGBP Double Nickase Plasmid (h2) - sc-412497-NIC-2 from Santa Cruz Biotechnology
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MRGBP CRISPR Activation Plasmid (h) - sc-412497-ACT from Santa Cruz Biotechnology
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MRGBP CRISPR Activation Plasmid (h2) - sc-412497-ACT-2 from Santa Cruz Biotechnology
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MRGBP Lentiviral Activation Particles (h) - sc-412497-LAC from Santa Cruz Biotechnology
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MRGBP Lentiviral Activation Particles (h2) - sc-412497-LAC-2 from Santa Cruz Biotechnology
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MRGBP siRNA (h) - sc-75822 from Santa Cruz Biotechnology
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MRGBP shRNA Plasmid (h) - sc-75822-SH from Santa Cruz Biotechnology
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MRGBP shRNA (h) Lentiviral Particles - sc-75822-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4734 from Sigma-Aldrich
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MRGBP siRNA (Human) - CRJ0602 from Cohesion Biosciences
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shRNA set against Human C20orf20 (NM_018270.4) - SHH251033 from Creative biogene
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Human MRGBP siRNA - orb271103 from Biorbyt
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MRGBP shRNA Plasmid (Human) - CHJ0602 from Cohesion Biosciences
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MRGBP miRNA 3'UTR clone - MiUTR3H-11679 from Creative biogene
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