| Gene Symbol | C8G |
|---|---|
| Entrez Gene | 733 |
| Alt Symbol | C8C |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 8, gamma polypeptide |
| Other Description | complement component C8 gamma chain |
| Swissprots | Q5SQ07 Q14CU0 P07360 Q14CT8 |
| Accessions | AAA18482 EAW88316 P07360 AW663384 BC113624 AAI13625 BC113626 AAI13627 BM852158 BX282392 HQ258743 ADR83494 M17263 AAA51888 M17999 AAA51863 X06465 CAA29773 XR_245338 NM_000606 NP_000597 |
| Function | C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis |