Gene Symbol | C8G |
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Entrez Gene | 733 |
Alt Symbol | C8C |
Species | Human |
Gene Type | protein-coding |
Description | complement component 8, gamma polypeptide |
Other Description | complement component C8 gamma chain |
Swissprots | Q5SQ07 Q14CU0 P07360 Q14CT8 |
Accessions | AAA18482 EAW88316 P07360 AW663384 BC113624 AAI13625 BC113626 AAI13627 BM852158 BX282392 HQ258743 ADR83494 M17263 AAA51888 M17999 AAA51863 X06465 CAA29773 XR_245338 NM_000606 NP_000597 |
Function | C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. |
Subcellular Location | Secreted. |
Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis |
C8γ CRISPR/Cas9 KO Plasmid (h) - sc-407017 from Santa Cruz Biotechnology
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C8γ HDR Plasmid (h) - sc-407017-HDR from Santa Cruz Biotechnology
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C8γ Double Nickase Plasmid (h) - sc-407017-NIC from Santa Cruz Biotechnology
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C8γ Double Nickase Plasmid (h2) - sc-407017-NIC-2 from Santa Cruz Biotechnology
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C8γ CRISPR Activation Plasmid (h) - sc-407017-ACT from Santa Cruz Biotechnology
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C8γ CRISPR Activation Plasmid (h2) - sc-407017-ACT-2 from Santa Cruz Biotechnology
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C8γ Lentiviral Activation Particles (h) - sc-407017-LAC from Santa Cruz Biotechnology
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C8γ Lentiviral Activation Particles (h2) - sc-407017-LAC-2 from Santa Cruz Biotechnology
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C8γ siRNA (h) - sc-92621 from Santa Cruz Biotechnology
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C8γ shRNA Plasmid (h) - sc-92621-SH from Santa Cruz Biotechnology
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C8γ shRNA (h) Lentiviral Particles - sc-92621-V from Santa Cruz Biotechnology
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C8G RNAi - H00000733-R01 from Novus Biologicals
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MISSION® esiRNA - EHU008261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5125 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5125 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00236 from Sigma-Aldrich
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C8G siRNA (Human) - CRH0510 from Cohesion Biosciences
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C8G - MBS8216584 from MyBioSource
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shRNA set against Human C8G (NM_000606.2) - SHH252605 from Creative biogene
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shRNA set against Human C8G(NM_000606.2) - SHG128809 from Creative biogene
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Human C8G siRNA - orb261012 from Biorbyt
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C8G shRNA Plasmid (Human) - CHH0510 from Cohesion Biosciences
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C8G miRNA 3'UTR clone - MiUTR1H-01495 from Creative biogene
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