| Gene Symbol |
C8G
|
| Entrez Gene |
733
|
| Alt Symbol |
C8C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 8, gamma polypeptide
|
| Other Description |
complement component C8 gamma chain
|
| Swissprots |
Q5SQ07 Q14CU0 P07360 Q14CT8
|
| Accessions |
AAA18482 EAW88316 P07360 AW663384 BC113624 AAI13625 BC113626 AAI13627 BM852158 BX282392 HQ258743 ADR83494 M17263 AAA51888 M17999 AAA51863 X06465 CAA29773 XR_245338 NM_000606 NP_000597
|
| Function |
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis
|
