| Gene Symbol |
Ubxn1
|
| Entrez Gene |
225896
|
| Alt Symbol |
2B28, 4930455J02Rik, D19Ertd721e, T25529
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
UBX domain protein 1
|
| Other Description |
SAPK substrate protein 1|UBA/UBX 33.3 kDa protein|UBX domain-containing protein 1|mY33K|protein 2B28
|
| Swissprots |
Q922Y1 Q3UCP8
|
| Accessions |
EDL33390 EDL33391 Q922Y1 AK015468 AK150442 BAE29564 AK159708 AK172428 AK185583 BC006701 AAH06701 XM_006526922 XP_006526985 NM_146093 NP_666205
|
| Function |
Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems. {ECO:0000250, ECO:0000269|PubMed:16709668}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15944415}.
|