Gene Symbol | Ubxn1 |
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Entrez Gene | 225896 |
Alt Symbol | 2B28, 4930455J02Rik, D19Ertd721e, T25529 |
Species | Mouse |
Gene Type | protein-coding |
Description | UBX domain protein 1 |
Other Description | SAPK substrate protein 1|UBA/UBX 33.3 kDa protein|UBX domain-containing protein 1|mY33K|protein 2B28 |
Swissprots | Q922Y1 Q3UCP8 |
Accessions | EDL33390 EDL33391 Q922Y1 AK015468 AK150442 BAE29564 AK159708 AK172428 AK185583 BC006701 AAH06701 XM_006526922 XP_006526985 NM_146093 NP_666205 |
Function | Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems. {ECO:0000250, ECO:0000269|PubMed:16709668}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15944415}. |
2B28 CRISPR/Cas9 KO Plasmid (m) - sc-432576 from Santa Cruz Biotechnology
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2B28 HDR Plasmid (m) - sc-432576-HDR from Santa Cruz Biotechnology
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2B28 Double Nickase Plasmid (m) - sc-432576-NIC from Santa Cruz Biotechnology
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2B28 Double Nickase Plasmid (m2) - sc-432576-NIC-2 from Santa Cruz Biotechnology
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2B28 CRISPR Activation Plasmid (m) - sc-432576-ACT from Santa Cruz Biotechnology
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2B28 CRISPR Activation Plasmid (m2) - sc-432576-ACT-2 from Santa Cruz Biotechnology
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2B28 Lentiviral Activation Particles (m) - sc-432576-LAC from Santa Cruz Biotechnology
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2B28 Lentiviral Activation Particles (m2) - sc-432576-LAC-2 from Santa Cruz Biotechnology
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βB28 siRNA (m) - sc-108883 from Santa Cruz Biotechnology
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2B28 shRNA Plasmid (m) - sc-108883-SH from Santa Cruz Biotechnology
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2B28 shRNA (m) Lentiviral Particles - sc-108883-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU023641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43863 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43863 from Sigma-Aldrich
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UBXN1 siRNA (Mouse) - CRN2464 from Cohesion Biosciences
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UBXN1 - MBS8231813 from MyBioSource
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shRNA set against Mouse UBXN1 (NM_146093.1) - SHH439648 from Creative biogene
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shRNA set against Mouse D19Ertd721e(NM_146093.1) - SHG219187 from Creative biogene
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Mouse UBXN1 siRNA - orb291939 from Biorbyt
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UBXN1 shRNA Plasmid (Mouse) - CHN2464 from Cohesion Biosciences
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UBXN1 miRNA 3'UTR clone - MiUTR1M-03611 from Creative biogene
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