NCBP1

Gene Symbol NCBP1
Entrez Gene 4686
Alt Symbol CBP80, NCBP, Sto1
Species Human
Gene Type protein-coding
Description nuclear cap binding protein subunit 1, 80kDa
Other Description 80 kDa nuclear cap-binding protein|NCBP 80 kDa subunit|nuclear cap binding protein subunit 1, 80kD|nuclear cap-binding protein subunit 1
Swissprots Q5T7X2 Q5T1V0 Q59G76 B2R718 Q09161
Accessions EAW58852 EAW58853 EAW58854 Q09161 AB209233 BAD92470 AK312807 BAG35665 BC001450 AAH01450 CA418527 D32002 BAA06769 DB086376 DQ895382 ABM86308 EU176351 ABW03802 X80030 CAA56334 XM_011518709 XP_011517011 XM_011518710 XP_011517012 XM_011518711 XP_011517013 XM_011518712 XP_011517014 XM_011518713 XP_011517015 XM_011518714 XP_011517016 XM_011518715 XP_011517017 NM_002486 NP_002477
Function Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC comp
Subcellular Location Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway

NCBP1/CBP80 Antibody - 9983 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using NCBP1/CBP80 Antibody.

CBP80 (E-7) - sc-271304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBP80 (E-7): sc-271304. Western blot analysis of CBP80 expression in Jurkat (A) and HeLa (B) nuclear extracts and A-431 whole cell lysate (C).

CBP80 (G-4) - sc-271305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBP80 (G-4): sc-271305. Western blot analysis of CBP80 expression in Jurkat (A) and HeLa (B) nuclear extracts and A-431 whole cell lysate (C).

CBP80 (H-300) - sc-48803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBP80 (H-300): sc-48803. Western blot analysis of CBP80 expression in non-transfected 293T: sc-117752 (A), human CBP80 transfected 293T: sc-175330 (B) and Jurkat (C) whole cell lysates.

CBP80 (N-14) - sc-19973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBP80 (N-14): sc-19973. Western blot analysis of CBP80 expression in Jurkat (A), KNRK (B), HL-60 (C) and K-562 (D) whole cell lysates.

Anti-NCBP1 antibody - ab181401 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-NCBP1 antibody (ab181401) at 1 µg/mlLane 2 : Anti-NCBP1 antibody (ab181401) at 2 µg/mlLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLysates/proteins at 15 µg per lane.

Anti-NCBP1 antibody - ab64837 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NCBP1 antibody (ab64837) at 1/500 dilutionLane 1 : HT29 cell extractLane 2 : LOVO cell extractLane 3 : LOVO cell extract with immunizing peptide

Anti-NCBP1 antibody - ab58706 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 antibody - C-terminal - ab156262 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NCBP1 antibody - C-terminal (ab156262) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-NCBP1 / CBP80 Antibody (N-Terminus) - LS-C46889 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (clone 1E9) - LS-C133918 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E9

Anti-NCBP1 / CBP80 Antibody (aa647-675, AP) - LS-C264070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (aa647-675, Biotin) - LS-C264072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (aa647-675, APC) - LS-C264071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (aa647-675, FITC) - LS-C264073 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (N-Terminus) - LS-C110514 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NCBP1 antibody LS-C110514 Western blot of 293T cell lysate.

Anti-NCBP1 / CBP80 Antibody (aa647-675, PE) - LS-C264075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (aa647-675, Azide-free, HRP) - LS-C264074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (aa647-675) - LS-C323249 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCBP1 / CBP80 Antibody (Arg5) - LS-C176801 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CBP80 (R5) pAb in extracts from HeLa cells.

Anti-NCBP1 / CBP80 Antibody (aa647-675) - LS-C157990 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NCBP1 Antibody western blot of 293 cell line lysates (35 ug/lane). The NCBP1 antibody detected the NCBP1 protein (arrow).

Anti-NCBP1 / CBP80 Antibody (aa1-50) - LS-C288574 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-NCBP1 / CBP80 Antibody (aa1-50) - LS-C118997 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HT-29/LOVO cells, using NCBP1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NCBP1 / CBP80 Antibody (aa482-532) - LS-C286867 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:250.

Anti-NCBP1 / CBP80 Antibody (aa482-532) - LS-C288575 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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