NCBP1

Gene Symbol	NCBP1
Entrez Gene	4686
Alt Symbol	CBP80, NCBP, Sto1
Species	Human
Gene Type	protein-coding
Description	nuclear cap binding protein subunit 1, 80kDa
Other Description	80 kDa nuclear cap-binding protein|NCBP 80 kDa subunit|nuclear cap binding protein subunit 1, 80kD|nuclear cap-binding protein subunit 1
Swissprots	Q5T7X2 Q5T1V0 Q59G76 B2R718 Q09161
Accessions	EAW58852 EAW58853 EAW58854 Q09161 AB209233 BAD92470 AK312807 BAG35665 BC001450 AAH01450 CA418527 D32002 BAA06769 DB086376 DQ895382 ABM86308 EU176351 ABW03802 X80030 CAA56334 XM_011518709 XP_011517011 XM_011518710 XP_011517012 XM_011518711 XP_011517013 XM_011518712 XP_011517014 XM_011518713 XP_011517015 XM_011518714 XP_011517016 XM_011518715 XP_011517017 NM_002486 NP_002477
Function	Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC comp
Subcellular Location	Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NCBP1 full length protein - ab114735 from Abcam Category Protein Source Wheat germ Species Human

Human NCBP1 full length protein - ab114736 from Abcam Category Protein Source Wheat germ Species Human

Human NCBP1 peptide - ab42387 from Abcam Category Peptide

Human NCBP1 peptide - ab42388 from Abcam Category Peptide

Human NCBP1 protein fragment - ab114737 from Abcam Category Protein Source Wheat germ Species Human

NCBP1 / CBP80 Antibody Blocking Peptide - LS-E14725 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCBP1 / CBP80 Antibody Blocking Peptide - LS-E31454 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human NCBP1 Protein - H00004686-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NCBP1 Protein - H00004686-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NCBP1 Protein - H00004686-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CBP80 blocking peptide - GTX89429-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

NCBP1 Blocking Peptide - 33R-8773 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NCBP1 - H00004686-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

NCBP1 - H00004686-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

NCBP1 - H00004686-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NCBP1 - H00004686-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NCBP1 - H00004686-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NCBP1 - H00004686-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NCBP1 Peptide - 7395P from ProSci Category Peptide Species Human

CBP80 fusion protein - ag0496 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NCBP1 - NCBP1-27855TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human NCBP1 - NCBP1-29240TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human NCBP1 - NCBP1-29294TH from Creative Biomart Category Protein Source Wheat germ Species Human

CBP80 (R5) Peptide - BS2040P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Nuclear cap-binding protein subunit 1(NCBP1) - CSB-YP600211HU CSB-EP600211HU CSB-BP600211HU CSB-MP600211HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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