| Gene Symbol | NCBP1 |
|---|---|
| Entrez Gene | 4686 |
| Alt Symbol | CBP80, NCBP, Sto1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear cap binding protein subunit 1, 80kDa |
| Other Description | 80 kDa nuclear cap-binding protein|NCBP 80 kDa subunit|nuclear cap binding protein subunit 1, 80kD|nuclear cap-binding protein subunit 1 |
| Swissprots | Q5T7X2 Q5T1V0 Q59G76 B2R718 Q09161 |
| Accessions | EAW58852 EAW58853 EAW58854 Q09161 AB209233 BAD92470 AK312807 BAG35665 BC001450 AAH01450 CA418527 D32002 BAA06769 DB086376 DQ895382 ABM86308 EU176351 ABW03802 X80030 CAA56334 XM_011518709 XP_011517011 XM_011518710 XP_011517012 XM_011518711 XP_011517013 XM_011518712 XP_011517014 XM_011518713 XP_011517015 XM_011518714 XP_011517016 XM_011518715 XP_011517017 NM_002486 NP_002477 |
| Function | Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC comp |
| Subcellular Location | Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Top Pathways | Spliceosome, RNA transport, mRNA surveillance pathway |