| Gene Symbol |
TIPIN
|
| Entrez Gene |
54962
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TIMELESS interacting protein
|
| Other Description |
CSM3 homolog|TIMELESS-interacting protein
|
| Swissprots |
Q9NWZ6 Q9BVW5 B2CW64
|
| Accessions |
ACB21044 EAW77762 EAW77763 Q9BVW5 AK000523 BAA91229 AK299233 BAG61265 BC000870 AAH00870 BK001386 DAA01365 BU596053 BU688750 XM_005254521 XP_005254578 XM_005254522 XP_005254579 XM_006720594 XP_006720657 XM_011521743 XP_011520045 NM_001289986 NP_001276915 NM_017858 NP_060328
|
| Function |
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|