| Gene Symbol |
INIP
|
| Entrez Gene |
616784
|
| Alt Symbol |
C8H9orf80, C9orf80, SSBIP1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
INTS3 and NABP interacting protein
|
| Other Description |
INTS3- and NABP-interacting protein|SOSS complex subunit C|SOSS-C|SSB-interacting protein 1|sensor of single-strand DNA complex subunit C|sensor of ssDNA subunit C|single-stranded DNA-binding protein-interacting protein 1
|
| Swissprots |
Q2NKT2
|
| Accessions |
DAA26475 Q2NKT2 BC111656 AAI11657 NM_001078064 NP_001071532
|
| Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000250}.
|