Gene Symbol | ICAM1 |
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Entrez Gene | 3383 |
Alt Symbol | BB2, CD54, P3.58 |
Species | Human |
Gene Type | protein-coding |
Description | intercellular adhesion molecule 1 |
Other Description | ICAM-1|cell surface glycoprotein P3.58|intercellular adhesion molecule 1 (CD54), human rhinovirus receptor|major group rhinovirus receptor |
Swissprots | Q5NKV7 P05362 Q96B50 B2R6M3 |
Accessions | AAA52710 AAB51145 AAO30128 CAA40441 CAA41977 EAW84086 EAW84087 P05362 AF340038 AAQ14901 AF340039 AAQ14902 AK130659 AK298054 BAG60348 AK298983 BAG61077 AK301412 BAG62944 AK312636 BAG35520 BC015969 AAH15969 BG149901 BP346334 BT006854 AAP35500 DQ890615 ABM92232 DQ893785 ABM84711 J03132 AAA52709 M24283 AAA52708 M55024 AAA60392 M55038 AAA60393 M55091 M55100 S82847 AAB46863 X06990 CAA30051 NM_000201 NP_000192 |
Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Epstein-Barr virus infection, Influenza A, TNF signaling pathway, Natural killer cell mediated cytotoxicity, HTLV-I infection |
Active human ICAM1 protein fragment - ab168688 from Abcam
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Active human ICAM1 protein fragment - ab82125 from Abcam
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Human ICAM1 full length protein - ab132925 from Abcam
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Human ICAM1 peptide - ab74481 from Abcam
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Human ICAM1 protein fragment - ab151393 from Abcam
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Human ICAM1 protein fragment - ab53501 from Abcam
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ICAM-1 / CD54 Antibody Blocking Peptide - LS-E21626 from LifeSpan Bioscience
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ICAM-1 / CD54 Antibody Blocking Peptide - LS-E27984 from LifeSpan Bioscience
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Recombinant Human ICAM-1/CD54 Protein - H00003383-P01 from Novus Biologicals
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Recombinant ICAM-1/CD54 Protein - NBP1-92654 from Novus Biologicals
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ICAM-1/CD54 Recombinant Protein - H00003383-G01 from Novus Biologicals
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ICAM-1 Recombinant Protein (Active) - GTX48197-PRO from GeneTex
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Recombinant Human ICAM-1/CD54 Fc Chimera, CF - 720-IC-050 from R&D Systems
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Recombinant Human ICAM-1/CD54 Fc Chimera, CF - 720-IC-200 from R&D Systems
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Recombinant Mouse ICAM-1/CD54 Fc Chimera, CF - 796-IC-050 from R&D Systems
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Recombinant Human ICAM-1/CD54, CF - ADP4-050 from R&D Systems
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Recombinant Human ICAM-1/CD54, CF - ADP4-200 from R&D Systems
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Recombinant human Intercellular adhesion molecule 1 (OPCA00684) - OPCA00684 from Aviva Systems Biology
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ICAM-1 Protein (OPPA01295) - OPPA01295 from Aviva Systems Biology
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Human CD54 Protein (OPSA11770) - OPSA11770 from Aviva Systems Biology
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Human Intercellular Adhesion Molecule 1 protein - orb83188 from Biorbyt
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Mouse Intercellular Adhesion Molecule 1 protein - orb83581 from Biorbyt
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Human Intercellular Adhesion Molecule 1 protein - orb83349 from Biorbyt
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Human sICAM-1 protein - orb245317 from Biorbyt
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Human ICAM1 protein - orb49452 from Biorbyt
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