EFNB2

Gene Symbol	EFNB2
Entrez Gene	1948
Alt Symbol	EPLG5, HTKL, Htk-L, LERK5
Species	Human
Gene Type	protein-coding
Description	ephrin-B2
Other Description	HTK ligand|LERK-5|eph-related receptor tyrosine kinase ligand 5|ligand of eph-related kinase 5
Swissprots	P52799 Q5JV56
Accessions	CAD91556 EAX09085 P52799 BC069342 AAH69342 BC074856 AAH74856 BC074857 AAH74857 BC105955 AAI05956 BC105956 AAI05957 BC105957 AAI05958 BG741114 BQ029549 BQ433342 BQ708550 BU622947 CB998384 DR004737 HQ448461 ADQ32941 L38734 AAC41752 U16797 AAA99707 U81262 AAD03786 NM_004093 NP_004084
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Lung and kidney.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ephrin B2 full length protein - ab132951 from Abcam Category Protein Source Wheat germ Species Human

Human Ephrin B2 protein fragment - ab92862 from Abcam Category Protein Source HEK 293 cells Species Human

Human Ephrin B2 protein fragment - ab113609 from Abcam Category Protein Source E. coli Species Human

Human Ephrin B2 protein fragment - ab151892 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse Ephrin B2 protein fragment - ab185427 from Abcam Category Protein Source Mammalian Species Mouse

EFNB2 / Ephrin B2 Antibody Blocking Peptide - LS-E1129 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EFNB2 / Ephrin B2 Antibody Blocking Peptide - LS-E27443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Ephrin B2 Partial Recombinant Protein - H00001948-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Ephrin B2 Recombinant Protein - H00001948-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Ephrin-B2 Protein - NBP1-72462 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

EFNB2-Antibody-Center-Blocking-peptide - BP11652c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ephrin B2 blocking peptide - GTX88049-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Recombinant Human Ephrin-B2 Fc Chimera, CF - 7397-EB-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human EPHRIN B2 Protein (OPSA11079) - OPSA11079 from Aviva Systems Biology Category Protein Prices $530.00 Sizes 25 µg Species Human

Human EphrinB2 protein - orb49361 from Biorbyt Category Protein Prices $179.00, $264.00, $995.00, $1,386.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human EFNB2 protein - orb168272 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

EFNB2 Immunizing peptide - orb59888 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

EFNB2 protein (His tag) - 80R-1976 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Ephrin B2 Peptide - AC21-2267-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Ephrin-B2 (28-229, His-tag) - AR50045PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Ephrin-B2 (28-229, His-tag) - AR50045PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Ephrin-B2 - H00001948-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Ephrin-B2 - H00001948-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Ephrin-B2 - H00001948-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Ephrin-B2 - H00001948-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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