Gene Symbol | Mcoln1 |
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Entrez Gene | 94178 |
Alt Symbol | 2210015I05Rik, TRPML1, mucolipidin |
Species | Mouse |
Gene Type | protein-coding |
Description | mucolipin 1 |
Other Description | mucolipin-1 |
Swissprots | Q99J21 |
Accessions | EDL21910 EDL21911 EDL21912 Q99J21 AF302009 AAL58667 AK008732 AK028385 BAC25922 AK032531 AK034471 BAC28719 AK038594 AK049606 BAC33838 AK195153 AK203892 BC005651 AAH05651 BC020377 XR_378673 NM_053177 NP_444407 |
Function | Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed, with the highest expression in brain, liver and kidney. {ECO:0000269|PubMed:11897010}. |
Top Pathways | Lysosome |
mucolipin 1 CRISPR/Cas9 KO Plasmid (m) - sc-430117 from Santa Cruz Biotechnology
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mucolipin 1 HDR Plasmid (m) - sc-430117-HDR from Santa Cruz Biotechnology
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mucolipin 1 Double Nickase Plasmid (m) - sc-430117-NIC from Santa Cruz Biotechnology
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mucolipin 1 Double Nickase Plasmid (m2) - sc-430117-NIC-2 from Santa Cruz Biotechnology
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mucolipin 1 CRISPR Activation Plasmid (m) - sc-430117-ACT from Santa Cruz Biotechnology
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mucolipin 1 CRISPR Activation Plasmid (m2) - sc-430117-ACT-2 from Santa Cruz Biotechnology
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mucolipin 1 Lentiviral Activation Particles (m) - sc-430117-LAC from Santa Cruz Biotechnology
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mucolipin 1 Lentiviral Activation Particles (m2) - sc-430117-LAC-2 from Santa Cruz Biotechnology
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mucolipin 1 siRNA (m) - sc-44520 from Santa Cruz Biotechnology
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mucolipin 1 shRNA Plasmid (m) - sc-44520-SH from Santa Cruz Biotechnology
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mucolipin 1 shRNA (m) Lentiviral Particles - sc-44520-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU030471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35377 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35377 from Sigma-Aldrich
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MCOLN1 siRNA (Mouse) - CRN0306 from Cohesion Biosciences
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shRNA set against Mouse MCOLN1 (NM_053177.1) - SHH339403 from Creative biogene
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shRNA set against Mouse Mcoln1(NM_053177.1) - SHH181649 from Creative biogene
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Mouse MCOLN1 siRNA - orb289781 from Biorbyt
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MCOLN1 shRNA Plasmid (Mouse) - CHN0306 from Cohesion Biosciences
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MCOLN1 miRNA 3'UTR clone - MiUTR1M-07003 from Creative biogene
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