| Gene Symbol |
CNOT4
|
| Entrez Gene |
4850
|
| Alt Symbol |
CLONE243, NOT4, NOT4H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 4
|
| Other Description |
CCR4-NOT transcription complex subunit 4|CCR4-associated factor 4|E3 ubiquitin-protein ligase CNOT4|NOT4 (negative regulator of transcription 4, yeast) homolog|potential transcriptional repressor NOT4Hp
|
| Swissprots |
E7ET38 Q8NCL0 O95339 F8VQP3 B7Z6I4 O95627 Q9NPQ1 Q8IYM7 Q9NZN6 O95628
|
| Accessions |
EAW83849 EAW83850 EAW83851 EAW83852 EAW83853 EAW83854 O95628 AF091094 AAC72963 AF180475 AAF29829 AK074493 BAG51961 AK074671 BAC11125 AK300365 BAH13270 AK314540 AL389980 CAB97536 AL519669 BC035590 AAH35590 CA396599 DA247976 U71267 AAD00179 U71268 AAD00180 XM_011516252 XP_011514554 NM_001008225 NP_001008226 NM_001190847 NP_001177776 NM_001190848 NP_001177777 NM_001190849 NP_001177778 NM_001190850 NP_001177779 NM_013316 NP_037448
|
| Function |
Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway. {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:22159038}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: CNOT4 Overexpression Lysate (Adult Normal) [NBL1-09319] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOT4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8376_CNOT4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09319-img0002.jpg)
![Western Blot: CNOT4 Overexpression Lysate (Adult Normal) [NBP2-07425] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOT4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9864_CNOT4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07425-img0001.jpg)