Gene Symbol | CNOT4 |
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Entrez Gene | 4850 |
Alt Symbol | CLONE243, NOT4, NOT4H |
Species | Human |
Gene Type | protein-coding |
Description | CCR4-NOT transcription complex, subunit 4 |
Other Description | CCR4-NOT transcription complex subunit 4|CCR4-associated factor 4|E3 ubiquitin-protein ligase CNOT4|NOT4 (negative regulator of transcription 4, yeast) homolog|potential transcriptional repressor NOT4Hp |
Swissprots | E7ET38 Q8NCL0 O95339 F8VQP3 B7Z6I4 O95627 Q9NPQ1 Q8IYM7 Q9NZN6 O95628 |
Accessions | EAW83849 EAW83850 EAW83851 EAW83852 EAW83853 EAW83854 O95628 AF091094 AAC72963 AF180475 AAF29829 AK074493 BAG51961 AK074671 BAC11125 AK300365 BAH13270 AK314540 AL389980 CAB97536 AL519669 BC035590 AAH35590 CA396599 DA247976 U71267 AAD00179 U71268 AAD00180 XM_011516252 XP_011514554 NM_001008225 NP_001008226 NM_001190847 NP_001177776 NM_001190848 NP_001177777 NM_001190849 NP_001177778 NM_001190850 NP_001177779 NM_013316 NP_037448 |
Function | Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway. {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:22159038}. |
Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. |
Top Pathways | RNA degradation |
CNOT4 CRISPR/Cas9 KO Plasmid (h) - sc-409657 from Santa Cruz Biotechnology
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CNOT4 HDR Plasmid (h) - sc-409657-HDR from Santa Cruz Biotechnology
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CNOT4 Double Nickase Plasmid (h) - sc-409657-NIC from Santa Cruz Biotechnology
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CNOT4 Double Nickase Plasmid (h2) - sc-409657-NIC-2 from Santa Cruz Biotechnology
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CNOT4 CRISPR Activation Plasmid (h) - sc-409657-ACT from Santa Cruz Biotechnology
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CNOT4 CRISPR Activation Plasmid (h2) - sc-409657-ACT-2 from Santa Cruz Biotechnology
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CNOT4 Lentiviral Activation Particles (h) - sc-409657-LAC from Santa Cruz Biotechnology
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CNOT4 Lentiviral Activation Particles (h2) - sc-409657-LAC-2 from Santa Cruz Biotechnology
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CNOT4 siRNA (h) - sc-72941 from Santa Cruz Biotechnology
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CNOT4 shRNA Plasmid (h) - sc-72941-SH from Santa Cruz Biotechnology
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CNOT4 shRNA (h) Lentiviral Particles - sc-72941-V from Santa Cruz Biotechnology
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CNOT4 RNAi - H00004850-R01 from Novus Biologicals
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CNOT4 RNAi - H00004850-R02 from Novus Biologicals
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MISSION® esiRNA - EHU139721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6322 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6322 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07821 from Sigma-Aldrich
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CNOT4 siRNA (Human) - CRH3222 from Cohesion Biosciences
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CNOT4 - MBS8222984 from MyBioSource
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shRNA set against Human CNOT4 (NM_013316.3) - SHH266449 from Creative biogene
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Human CNOT4 siRNA - orb263724 from Biorbyt
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CNOT4 shRNA Plasmid (Human) - CHH3222 from Cohesion Biosciences
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CNOT4 miRNA 3'UTR clone - MiUTR3H-07198 from Creative biogene
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CNOT4 miRNA 3'UTR clone - MiUTR3H-07199 from Creative biogene
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