CLOCK

Gene Symbol	CLOCK
Entrez Gene	9575
Alt Symbol	KAT13D, bHLHe8
Species	Human
Gene Type	protein-coding
Description	clock circadian regulator
Other Description	circadian locomoter output cycles kaput protein|circadian locomoter output cycles protein kaput|class E basic helix-loop-helix protein 8|clock homolog
Swissprots	A0AV01 Q9UIT8 O14516 A2I2N9 O15516
Accessions	AAF70307 ABM64208 BAB88852 BAB92020 EAX05468 O15516 AB002332 BAA20792 AB005535 BAA21774 AF011568 AAB83969 AK096319 AK124437 AK223549 BAD97269 AK291708 BAF84397 BC040570 BC041878 AAH41878 BC126157 AAI26158 BC126159 AAI26160 BX537616 BX538337 DA658950 EU446690 ABZ92219 HQ258670 ADR83421 XM_005265787 XP_005265844 XM_006714054 XP_006714117 XM_011534409 XP_011532711 XM_011534410 XP_011532712 XM_011534411 XP_011532713 NM_001267843 NP_001254772 NM_004898 NP_004889
Function	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
Subcellular Location	Nucleus {ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23160374}. Cytoplasm {ECO:0000250|UniProtKB:O08785}. Note=Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL/BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:21659603}.
Tissue Specificity	Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN). {ECO:0000269|PubMed:10198158, ECO:0000269|PubMed:24005054}.
Top Pathways	Circadian rhythm, Herpes simplex infection, Dopaminergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KAT13D / CLOCK protein fragment - ab153001 from Abcam Category Protein Source Wheat germ Species Human

KAT13D / CLOCK peptide - ab5854 from Abcam Category Peptide

KAT13D / CLOCK peptide - ab5855 from Abcam Category Peptide

CLOCK Antibody Blocking Peptide - LS-E11926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLOCK Antibody Blocking Peptide - LS-E9074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLOCK Peptide - NBP1-30326PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 50 µg

Recombinant Human CLOCK Protein - H00009575-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CLOCK Protein - H00009575-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CLOCK Peptide - P2594 from Novus Biologicals Category Peptide Species Human

CLOCK-Antibody-C-term-Blocking-peptide - BP12261b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLOCK-Antibody-N-term-Blocking-peptide - BP12196a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLOCK-Antibody-Center-Blocking-Peptide - BP7582c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLOCK Blocking Peptide - 33R-10985 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CLOCK Blocking Peptide - abx161360 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Pig

KAT13D / CLOCK Peptide - AC21-2983-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CLOCK - H00009575-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CLOCK - H00009575-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CLOCK - H00009575-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLOCK - H00009575-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLOCK fusion protein - ag12826 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CLOCK, GST-tagged - CLOCK-11340H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CLOCK, GST-tagged - CLOCK-75H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Clock Homolog (CLOCK) - RPQ116Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

CLOCK Blocking Peptide - CBP3859 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Dog, Pig

Clock (E270) Peptide - BS1873P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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