| Gene Symbol |
CLOCK
|
| Entrez Gene |
9575
|
| Alt Symbol |
KAT13D, bHLHe8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
clock circadian regulator
|
| Other Description |
circadian locomoter output cycles kaput protein|circadian locomoter output cycles protein kaput|class E basic helix-loop-helix protein 8|clock homolog
|
| Swissprots |
A0AV01 Q9UIT8 O14516 A2I2N9 O15516
|
| Accessions |
AAF70307 ABM64208 BAB88852 BAB92020 EAX05468 O15516 AB002332 BAA20792 AB005535 BAA21774 AF011568 AAB83969 AK096319 AK124437 AK223549 BAD97269 AK291708 BAF84397 BC040570 BC041878 AAH41878 BC126157 AAI26158 BC126159 AAI26160 BX537616 BX538337 DA658950 EU446690 ABZ92219 HQ258670 ADR83421 XM_005265787 XP_005265844 XM_006714054 XP_006714117 XM_011534409 XP_011532711 XM_011534410 XP_011532712 XM_011534411 XP_011532713 NM_001267843 NP_001254772 NM_004898 NP_004889
|
| Function |
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23160374}. Cytoplasm {ECO:0000250|UniProtKB:O08785}. Note=Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL/BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:21659603}.
|
| Tissue Specificity |
Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN). {ECO:0000269|PubMed:10198158, ECO:0000269|PubMed:24005054}.
|
| Top Pathways |
Circadian rhythm, Herpes simplex infection, Dopaminergic synapse
|
