| Gene Symbol |
TP53INP2
|
| Entrez Gene |
58476
|
| Alt Symbol |
C20orf110, DOR, PINH, dJ1181N3.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor protein p53 inducible nuclear protein 2
|
| Other Description |
PIG-U|diabetes and obesity regulated|diabetes and obesity-regulated|p53-inducible protein U|tumor protein p53-inducible nuclear protein 2
|
| Swissprots |
Q9NU00 Q5JX64 Q8IYL5 Q8IXH6 A8K8S8 E1P5P6
|
| Accessions |
EAW76256 EAW76257 EAW76258 Q8IXH6 AJ297792 CAC82592 AK025412 AK027153 AK292443 BAF85132 AL122050 AL137597 AY422170 AAR23799 BC035639 AAH35639 XM_005260476 XP_005260533 XM_006723841 XP_006723904 XM_011528952 XP_011527254 XM_011528953 XP_011527255 NM_021202 NP_067025
|
| Function |
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269|PubMed:18030323, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22470510}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
|