HMGB1

Gene Symbol HMGB1
Entrez Gene 282691
Alt Symbol -
Species Bovine
Gene Type protein-coding
Description high mobility group box 1
Other Description HMG-1|high mobility group protein 1|high mobility group protein B1|high-mobility group box 1
Swissprots Q3ZC39 A5D9G8 P10103
Accessions DAA23902 P10103 BC102929 AAI02930 BT030587 ABQ13027 M26110 AAA30567 X12796 CAA31284 XM_005213558 XP_005213615 XM_010810664 XP_010808966 NM_176612 NP_788785
Function DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}.
Top Pathways Base excision repair

Anti-HMGB1 antibody [4C3] - ab11354 from Abcam

Prices $387.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4C3

Anti-HMGB1 antibody [GT348] - ab184532 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT348
Immunohistochemical analysis of paraffin-embedded U373 xenograft tissue labeling HMGB1 with ab184532 at 1/200 dilution.

Anti-HMGB1 antibody [GT383] - ab184203 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT383
All lanes : Anti-HMGB1 antibody [GT383] (ab184203) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : HepG2 whole cell lysateLane 5 : A375 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HMGB1 antibody (HRP) - ab128129 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HMGB1 antibody (HRP) (ab128129) at 1/5000 dilutionLane 1 : MEF1 (Mouse embryonic fibroblast cell line) Whole Cell LysateLane 2 : PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell LysateLane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-HMGB1 antibody - ChIP Grade - ab18256 from Abcam

Prices $404.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Image courtesy of Human Protein AtlasParaffin embedded sections of human liver were incubated with ab18256 (1/1000 dilution) for 30 minutes at room temperature. Heat induced antigen retrieval was performed in citrate buffer pH 6.ab18256 was tested in a tissue microarray (TMA) containing a wide range of normal and cancer tissues as well as a cell microarray consisting of a range of commonly used, well characterised human cell lines. Further images can be found www.proteinatlas.org
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