Gene Symbol | NT5C1A |
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Entrez Gene | 84618 |
Alt Symbol | CN-I, CN-IA, CN1, CN1A, CNI |
Species | Human |
Gene Type | protein-coding |
Description | 5'-nucleotidase, cytosolic IA |
Other Description | AMP-specific 5'-NT|cytosolic 5' nucleotidase, type 1A|cytosolic 5'-nucleotidase 1A|cytosolic 5'-nucleotidase IA |
Swissprots | Q9BWT8 Q5TG98 Q9BXI3 Q3SYB9 |
Accessions | EAX07259 Q9BXI3 AF331801 AAK01294 AY028778 AAK30000 BC103879 AAI03880 BC103880 AAI03881 NM_032526 NP_115915 |
Function | Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. {ECO:0000269|PubMed:11133996}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas. {ECO:0000269|PubMed:11133996}. |
Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |
NT5C1A CRISPR/Cas9 KO Plasmid (h) - sc-413671 from Santa Cruz Biotechnology
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NT5C1A HDR Plasmid (h) - sc-413671-HDR from Santa Cruz Biotechnology
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NT5C1A Double Nickase Plasmid (h) - sc-413671-NIC from Santa Cruz Biotechnology
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NT5C1A Double Nickase Plasmid (h2) - sc-413671-NIC-2 from Santa Cruz Biotechnology
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NT5C1A CRISPR Activation Plasmid (h) - sc-413671-ACT from Santa Cruz Biotechnology
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NT5C1A CRISPR Activation Plasmid (h2) - sc-413671-ACT-2 from Santa Cruz Biotechnology
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NT5C1A Lentiviral Activation Particles (h) - sc-413671-LAC from Santa Cruz Biotechnology
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NT5C1A Lentiviral Activation Particles (h2) - sc-413671-LAC-2 from Santa Cruz Biotechnology
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NT5C1A siRNA (h) - sc-78565 from Santa Cruz Biotechnology
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NT5C1A shRNA Plasmid (h) - sc-78565-SH from Santa Cruz Biotechnology
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NT5C1A shRNA (h) Lentiviral Particles - sc-78565-V from Santa Cruz Biotechnology
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NT5C1A RNAi - H00084618-R01 from Novus Biologicals
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MISSION® Human Phosphatase - SIHP0357 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0356 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0355 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15547 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15547 from Sigma-Aldrich
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NT5C1A siRNA (Human) - CRJ3534 from Cohesion Biosciences
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shRNA set against Human NT5C1A (NM_032526.1) - SHH355520 from Creative biogene
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Human NT5C1A siRNA - orb274035 from Biorbyt
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NT5C1A shRNA Plasmid (Human) - CHJ3534 from Cohesion Biosciences
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NT5C1A miRNA 3'UTR clone - MiUTR1H-06939 from Creative biogene
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