| Gene Symbol | PEX19 |
|---|---|
| Entrez Gene | 5824 |
| Alt Symbol | D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | peroxisomal biogenesis factor 19 |
| Other Description | 33 kDa housekeeping protein|housekeeping gene, 33kD|peroxin-19|peroxisomal farnesylated protein |
| Swissprots | D3DVE7 P40855 Q8NI97 Q5QNY4 |
| Accessions | CAA70257 EAW52727 EAW52728 EAW52729 P40855 AB018541 BAA76291 AB062286 BAB93469 AK300368 BAH13271 AK303099 BAH13899 AY434724 BC000496 AAH00496 BC064979 BT006879 AAP35525 CB993363 CD557913 DC400252 DC405033 DQ891417 ABM82343 DQ894591 ABM85517 X75535 CAA53225 NM_001193644 NP_001180573 NM_002857 NP_002848 NR_036492 NR_036493 NM_001131039 |
| Function | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| Subcellular Location | Cytoplasm. Peroxisome membrane; Lipid- anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes. |
| Tissue Specificity | Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. {ECO:0000269|PubMed:9339377}. |
| Top Pathways | Peroxisome |