PEX19

Gene Symbol PEX19
Entrez Gene 5824
Alt Symbol D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1
Species Human
Gene Type protein-coding
Description peroxisomal biogenesis factor 19
Other Description 33 kDa housekeeping protein|housekeeping gene, 33kD|peroxin-19|peroxisomal farnesylated protein
Swissprots D3DVE7 P40855 Q8NI97 Q5QNY4
Accessions CAA70257 EAW52727 EAW52728 EAW52729 P40855 AB018541 BAA76291 AB062286 BAB93469 AK300368 BAH13271 AK303099 BAH13899 AY434724 BC000496 AAH00496 BC064979 BT006879 AAP35525 CB993363 CD557913 DC400252 DC405033 DQ891417 ABM82343 DQ894591 ABM85517 X75535 CAA53225 NM_001193644 NP_001180573 NM_002857 NP_002848 NR_036492 NR_036493 NM_001131039
Function Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}.
Subcellular Location Cytoplasm. Peroxisome membrane; Lipid- anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
Tissue Specificity Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. {ECO:0000269|PubMed:9339377}.
Top Pathways Peroxisome

Peroxin 19 CRISPR/Cas9 KO Plasmid (h) - sc-416999 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 HDR Plasmid (h) - sc-416999-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 Double Nickase Plasmid (h) - sc-416999-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 Double Nickase Plasmid (h2) - sc-416999-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 CRISPR Activation Plasmid (h) - sc-416999-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 CRISPR Activation Plasmid (h2) - sc-416999-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 Lentiviral Activation Particles (h) - sc-416999-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 Lentiviral Activation Particles (h2) - sc-416999-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peroxin 19 siRNA (h) - sc-44925 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Peroxin 19 shRNA Plasmid (h) - sc-44925-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Peroxin 19 shRNA (h) Lentiviral Particles - sc-44925-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU044051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16638 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16638 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12957 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12957

PEX19 siRNA (Human) - CRH3936 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PEX19 (NM_002857.3) - SHH373732 from Creative biogene

Category siRNA
Species Reactivities Human

PEX19 shRNA Plasmid (Human) - CHH3936 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PEX19 miRNA 3'UTR clone - MiUTR4H-TG06614 from Creative biogene

Species Reactivities Human
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