Gene Symbol | DEFA4 |
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Entrez Gene | 1669 |
Alt Symbol | DEF4, HNP-4, HP-4, HP4 |
Species | Human |
Gene Type | protein-coding |
Description | defensin, alpha 4, corticostatin |
Other Description | corticostatin|defensin, alpha 4, preproprotein|neutrophil defensin 4 |
Swissprots | Q6EZF8 P12838 |
Accessions | AAA64488 AAT68877 CAM91151 EAW80486 P12838 BC093959 AAH93959 BC106747 AAI06748 BC112091 AAI12092 BU616655 DN998607 X65977 CAA46792 NM_001925 NP_001916 |
Function | Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15620707}. |
Subcellular Location | Secreted. |
α-defensin 4 CRISPR/Cas9 KO Plasmid (h) - sc-407288 from Santa Cruz Biotechnology
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α-defensin 4 HDR Plasmid (h) - sc-407288-HDR from Santa Cruz Biotechnology
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α-defensin 4 Double Nickase Plasmid (h) - sc-407288-NIC from Santa Cruz Biotechnology
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α-defensin 4 Double Nickase Plasmid (h2) - sc-407288-NIC-2 from Santa Cruz Biotechnology
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α-defensin 4 CRISPR Activation Plasmid (h) - sc-407288-ACT from Santa Cruz Biotechnology
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α-defensin 4 CRISPR Activation Plasmid (h2) - sc-407288-ACT-2 from Santa Cruz Biotechnology
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α-defensin 4 Lentiviral Activation Particles (h) - sc-407288-LAC from Santa Cruz Biotechnology
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α-defensin 4 Lentiviral Activation Particles (h2) - sc-407288-LAC-2 from Santa Cruz Biotechnology
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α -defensin 4 siRNA (h) - sc-60047 from Santa Cruz Biotechnology
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α-defensin 4 shRNA Plasmid (h) - sc-60047-SH from Santa Cruz Biotechnology
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α-defensin 4 shRNA (h) Lentiviral Particles - sc-60047-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7087 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7087 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01381 from Sigma-Aldrich
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DEFA4 siRNA (Human) - CRH1178 from Cohesion Biosciences
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DEFA4 - MBS8231707 from MyBioSource
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shRNA set against Human DEFA4 (NM_001925.1) - SHH276401 from Creative biogene
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shRNA set against Human DEFA4(NM_001925.1) - SHG228149 from Creative biogene
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Human DEFA4 siRNA - orb261680 from Biorbyt
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DEFA4 shRNA Plasmid (Human) - CHH1178 from Cohesion Biosciences
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DEFA4 miRNA 3'UTR clone - MiUTR1H-02752 from Creative biogene
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