Gene Symbol | SCNN1G |
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Entrez Gene | 6340 |
Alt Symbol | BESC3, ENaCg, ENaCgamma, PHA1, SCNEG |
Species | Human |
Gene Type | protein-coding |
Description | sodium channel, non voltage gated 1 gamma subunit |
Other Description | ENaC gamma subunit|amiloride-sensitive epithelial sodium channel gamma subunit|amiloride-sensitive sodium channel gamma-subunit|amiloride-sensitive sodium channel subunit gamma|epithelial Na(+) channel subunit gamma|gamma-ENaC|gamma-NaCH|nonvoltage-gated sodium channel 1 subunit gamma|sodium channel, non-voltage-gated 1, gamma subunit|sodium channel, nonvoltage-gated 1, gamma |
Swissprots | Q96TD2 Q93026 Q93027 P51170 Q6PCC2 P78437 Q93024 Q93025 Q93023 |
Accessions | AAC50217 AAC50744 AAC50745 AAC50746 AAC50747 AAC50748 AAC50749 AAC50750 AAC50751 AAC50752 AAC50753 AAC50754 AAC50755 AAC50756 AAC50757 AAC50758 AAC50759 AAC50760 AAC50761 AAK50910 ACS13725 CAB07506 EAW55837 EAW55838 P51170 BC059391 AAH59391 BC069652 AAH69652 DQ402524 ABD72220 L36592 AAA75460 U48936 AAC50737 X87160 CAA60633 NM_001039 NP_001030 |
Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}. |
Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:24124190}. Note=Apical membrane of epithelial cells. |
Tissue Specificity | Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}. |
Top Pathways | Taste transduction, Aldosterone-regulated sodium reabsorption |
epithelial Sodium Channel gamma peptide - ab4990 from Abcam
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Human epithelial Sodium Channel gamma full length protein - ab131898 from Abcam
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Human epithelial Sodium Channel gamma protein fragment - ab159483 from Abcam
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SCNN1G / ENaC Gamma Antibody Blocking Peptide - LS-E26895 from LifeSpan Bioscience
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Recombinant Human epithelial Sodium Channel gamma Protein - H00006340-Q01 from Novus Biologicals
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Recombinant Human epithelial Sodium Channel gamma Protein - H00006340-P02 from Novus Biologicals
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ENaC Gamma blocking peptide - GTX88544-PEP from GeneTex
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Epithelial Sodium Channel gamma Peptide - AC21-1728-P from Abcore
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ENAC gamma / SCNN1G - H00006340-P02 from Acris Antibodies
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ENAC gamma / SCNN1G - H00006340-P02-10 from Acris Antibodies
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ENAC gamma / SCNN1G - H00006340-P02-25 from Acris Antibodies
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ENAC gamma / SCNN1G - H00006340-Q01-10 from Acris Antibodies
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ENAC gamma / SCNN1G - H00006340-Q01-25 from Acris Antibodies
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SCNN1 gamma Peptide - 46-755P from ProSci
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SCNN1G fusion protein - Ag5286 from Proteintech Group
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SCNN1G fusion protein - ag5020 from Proteintech Group
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Recombinant Human SCNN1G, His-tagged - SCNN1G-2539H from Creative Biomart
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Recombinant Human SCNN1G, His-tagged - SCNN1G-3417H from Creative Biomart
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Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) - RPD335Hu01 from Uscn Life Science Inc.
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Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) - RPD335Hu01 from Cloud-clone
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Amiloride-sensitive amine oxidase [copper-containing] (ABP1) - MBS2030029 from MyBioSource
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Amiloride-sensitive sodium channel subunit gamma (SCNN1G) - MBS962076 from MyBioSource
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SCNN1G Protein - abx164206 from Abbexa
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SCNN1G , Peptide - MBS425436 from MyBioSource
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Gamma-NaCH Blocking Peptide - abx061995 from Abbexa
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