| Gene Symbol |
PIDD1
|
| Entrez Gene |
55367
|
| Alt Symbol |
LRDD, PIDD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
p53-induced death domain protein 1
|
| Other Description |
leucine-rich repeat and death domain-containing protein|leucine-rich repeats and death domain containing|p53-induced death domain-containing protein 1|p53-induced protein with a death domain
|
| Swissprots |
Q8NDL2 Q8NC89 Q59HC7 Q59H10 Q9NRE6 Q9HB75 Q59FD1 Q7Z4P8 Q96C25
|
| Accessions |
CCQ43600 EAX02390 EAX02391 EAX02392 Q9HB75 AB208832 BAD92069 AB208949 BAD92186 AB209529 BAD92766 AF229178 AAF69491 AF274972 AAG13461 AF465246 AAP97716 AK074893 BAC11272 AL833849 CAD38708 BC014904 AAH14904 BG723687 BQ059356 BQ214414 BQ924290 BX349115 CN427944 CN427946 EU176211 ABW03662 XM_005253005 XP_005253062 XM_005253006 XP_005253063 XM_005253007 XP_005253064 XM_005253008 XP_005253065 XM_011520209 XP_011518511 XM_011520210 XP_011518512 XM_011520211 XP_011518513 XM_011520212 XP_011518514 XM_011520213 XP_011518515 XR_930877 NM_145886 NP_665893 NM_145887 NP_665894 NM_018494
|
| Function |
Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. {ECO:0000269|PubMed:10973264, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16360037}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16360037}. Nucleus {ECO:0000269|PubMed:16360037}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10825539}.
|
| Top Pathways |
p53 signaling pathway
|