PIDD1

Gene Symbol PIDD1
Entrez Gene 55367
Alt Symbol LRDD, PIDD
Species Human
Gene Type protein-coding
Description p53-induced death domain protein 1
Other Description leucine-rich repeat and death domain-containing protein|leucine-rich repeats and death domain containing|p53-induced death domain-containing protein 1|p53-induced protein with a death domain
Swissprots Q8NDL2 Q8NC89 Q59HC7 Q59H10 Q9NRE6 Q9HB75 Q59FD1 Q7Z4P8 Q96C25
Accessions CCQ43600 EAX02390 EAX02391 EAX02392 Q9HB75 AB208832 BAD92069 AB208949 BAD92186 AB209529 BAD92766 AF229178 AAF69491 AF274972 AAG13461 AF465246 AAP97716 AK074893 BAC11272 AL833849 CAD38708 BC014904 AAH14904 BG723687 BQ059356 BQ214414 BQ924290 BX349115 CN427944 CN427946 EU176211 ABW03662 XM_005253005 XP_005253062 XM_005253006 XP_005253063 XM_005253007 XP_005253064 XM_005253008 XP_005253065 XM_011520209 XP_011518511 XM_011520210 XP_011518512 XM_011520211 XP_011518513 XM_011520212 XP_011518514 XM_011520213 XP_011518515 XR_930877 NM_145886 NP_665893 NM_145887 NP_665894 NM_018494
Function Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. {ECO:0000269|PubMed:10973264, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16360037}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16360037}. Nucleus {ECO:0000269|PubMed:16360037}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10825539}.
Top Pathways p53 signaling pathway

PIDD (S-17) - sc-32161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIDD (S-17): sc-32161. Western blot analysis of PIDD expression in 293T whole cell lysate.

PIDD (H-300) - sc-67032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PIDD (H-300): sc-67032. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing cytoplasmic and nuclear staining of epidermal cells.

PIDD (C-20) - sc-32163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIDD (C-20): sc-32163. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing cytoplasmic and nuclear staining of epidermal cells.

Anti-LRDD antibody - ab78389 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LRDD antibody (ab78389) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LRDD antibody - ab176611 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded pancreas cancer labeling LRDD at 1/100 dilution with ab176611 showing nuclear and cytoplasmic staining.

Anti-LRDD antibody - ab99149 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LRDD antibody (ab99149) at 1 µg/ml + Human Fetal Liver Lysate at 10 µg

Anti-PIDD1 Antibody (aa776-910) - LS-C345057 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PIDD1 Antibody (aa143-192) - LS-C112013 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRDD antibody LS-C112013 Western blot of Fetal Liver lysate.

Anti-PIDD1 Antibody (aa467-516) - LS-C116670 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRDD antibody LS-C116670 Western blot of NCI-H226 cell lysate.

Anti-PIDD1 Antibody (clone Lise-1) - LS-C344931 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Lise-1
Mouse PIDD is detected in primary MEF cells using anti-PIDD (mouse), mAb (Lise-1) . Method:: Cell extracts from mouse embryo fibroblasts (MEFs) either from WT (A-B) or PIDD KO cells (C-D) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-PIDD (mouse), mAb (Lise-1) (1ug/ml). Proteins were visualized by a chemiluminescence detection system.

Anti-PIDD Antibody (aa776-910) - LS-C17281 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

LRDD Antibody (Anto-1) - NBP1-97595 from Novus Biologicals

Prices $279.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone Anto-1
Western Blot: LRDD Antibody (Anto-1) [NBP1-97595] - Analysis of endogenous and overexpressed human PIDD using MAb to PIDD (Anto-1). Method: Cell extracts (1x10^5) from HEK 293T wild type (lane 1) or transfected with a plasmid coding for human PIDD (lane 2) were resolved by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with the MAb to PIDD (Anto-1) at a 1:500 dilution for 2 hours. Proteins were visualized using a peroxidase-conjugated polyclonal antibody to mouse IgG and a chemiluminescence detection system. Note that two major forms of PIDD are detected, representing full length and cleaved proteins, migrating at approximatively 90kDa and 50kDa, respectively.

LRDD Antibody - NBP1-57991 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRDD Antibody [NBP1-57991] - Human Liver cell lysate, concentration 0.2-1 ug/ml.

LRDD Antibody - NBP1-57990 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

LRDD Polyclonal Antibody - bs-7615R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LRDD (601-615) antibody produced in rabbit - L7419 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-LRDD (601-615): <B>Cat. No. L7419</B>: Immunofluorescence of HUVEC cells using LRDD (601-615) (RB),<B>Cat. No. L7419</B> (red) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-LRDD (796-810) antibody produced in rabbit - L7544 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-LRDD (796-810): <B>Cat. No. L7544</B>: Immunofluorescence of HUVEC cells using LRDD (796-810) (RB),<B>Cat. No. L7544</B> (red) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-PIDD (Anto-1) Antibody (OAED00370) - OAED00370 from Aviva Systems Biology

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Anto-1

LRDD antibody - N-terminal region (ARP57269_P050) - ARP57269_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LRDD antibody - middle region (ARP57270_P050) - ARP57270_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LRDD antibody, Internal - GTX44937 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

LRDD antibody, N-term - GTX44938 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

LRDD antibody - 70R-5426 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

LRDD antibody - 70R-18306 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

LRDD antibody - 70R-5425 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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