| Gene Symbol |
LIPI
|
| Entrez Gene |
149998
|
| Alt Symbol |
CT17, LPDL, PLA1C, PRED5, mPA-PLA1 beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipase, member I
|
| Other Description |
LPD lipase|cancer/testis antigen 17|lipase member I|membrane-associated phosphatidic acid-selective phospholipase A1-beta
|
| Swissprots |
Q6XZB0 G1JSG4 G1JSG6 G1JSG8 G1JSG7 G1JSG9 G1JSG3 G1JSG5
|
| Accessions |
Q6XZB0 AI017218 AY197607 AAP37476 AY918476 AAX14040 BC140336 AAI40337 BC148691 AAI48692 BI460152 JN387910 AEL12688 JN387911 AEL12689 JN387912 AEL12690 JN387913 AEL12691 JN387914 AEL12692 JN387915 AEL12693 JN387916 AEL12694 XM_006723965 XP_006724028 XM_006723966 XP_006724029 NM_001302998 NP_001289927 NM_001302999 NP_001289928 NM_001303000 NP_001289929 NM_001303001 NP_001289930 NM_198996 NP_945347 NM_145317
|
| Function |
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12963729}.
|
| Subcellular Location |
Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.
|
| Tissue Specificity |
Expressed in testis. Expressed exclusively at the connecting piece of the sperm. {ECO:0000269|PubMed:12719377, ECO:0000269|PubMed:12963729}.
|