Gene Symbol | LIPI |
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Entrez Gene | 149998 |
Alt Symbol | CT17, LPDL, PLA1C, PRED5, mPA-PLA1 beta |
Species | Human |
Gene Type | protein-coding |
Description | lipase, member I |
Other Description | LPD lipase|cancer/testis antigen 17|lipase member I|membrane-associated phosphatidic acid-selective phospholipase A1-beta |
Swissprots | Q6XZB0 G1JSG4 G1JSG6 G1JSG8 G1JSG7 G1JSG9 G1JSG3 G1JSG5 |
Accessions | Q6XZB0 AI017218 AY197607 AAP37476 AY918476 AAX14040 BC140336 AAI40337 BC148691 AAI48692 BI460152 JN387910 AEL12688 JN387911 AEL12689 JN387912 AEL12690 JN387913 AEL12691 JN387914 AEL12692 JN387915 AEL12693 JN387916 AEL12694 XM_006723965 XP_006724028 XM_006723966 XP_006724029 NM_001302998 NP_001289927 NM_001302999 NP_001289928 NM_001303000 NP_001289929 NM_001303001 NP_001289930 NM_198996 NP_945347 NM_145317 |
Function | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12963729}. |
Subcellular Location | Isoform 1: Membrane. Secreted. Note=May associate with lipid draft. |
Tissue Specificity | Expressed in testis. Expressed exclusively at the connecting piece of the sperm. {ECO:0000269|PubMed:12719377, ECO:0000269|PubMed:12963729}. |
LPD lipase CRISPR/Cas9 KO Plasmid (h) - sc-414670 from Santa Cruz Biotechnology
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LPD lipase HDR Plasmid (h) - sc-414670-HDR from Santa Cruz Biotechnology
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LPD lipase Double Nickase Plasmid (h) - sc-414670-NIC from Santa Cruz Biotechnology
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LPD lipase Double Nickase Plasmid (h2) - sc-414670-NIC-2 from Santa Cruz Biotechnology
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LPD lipase CRISPR Activation Plasmid (h) - sc-414670-ACT from Santa Cruz Biotechnology
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LPD lipase CRISPR Activation Plasmid (h2) - sc-414670-ACT-2 from Santa Cruz Biotechnology
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LPD lipase Lentiviral Activation Particles (h) - sc-414670-LAC from Santa Cruz Biotechnology
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LPD lipase Lentiviral Activation Particles (h2) - sc-414670-LAC-2 from Santa Cruz Biotechnology
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LPD lipase siRNA (h) - sc-91389 from Santa Cruz Biotechnology
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LPD lipase shRNA Plasmid (h) - sc-91389-SH from Santa Cruz Biotechnology
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LPD lipase shRNA (h) Lentiviral Particles - sc-91389-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2579 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2579 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00347 from Sigma-Aldrich
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LIPI siRNA (Human) - CRJ5636 from Cohesion Biosciences
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shRNA set against Human LIPI (NM_198996.2) - SHH330703 from Creative biogene
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LIPI shRNA Plasmid (Human) - CHJ5636 from Cohesion Biosciences
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LIPI miRNA 3'UTR clone - MiUTR1H-05700 from Creative biogene
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