| Gene Symbol |
EFHD2
|
| Entrez Gene |
79180
|
| Alt Symbol |
SWS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EF-hand domain family, member D2
|
| Other Description |
EF hand domain containing 2|EF hand domain family, member D2|EF-hand domain-containing protein D2|swiprosin 1|swiprosin-1
|
| Swissprots |
Q5JYW9 Q96C19
|
| Accessions |
EAW51720 EAW51721 EAW51722 EAW51723 Q96C19 AI624416 BC003033 BC007233 AAH07233 BC013648 BC014923 AAH14923 BC023611 AAH23611 BC068473 AAH68473 BI753983 BM796344 XM_005246000 XP_005246057 XM_011542114 XP_011540416 NM_024329 NP_077305
|
| Function |
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}.
|
| Subcellular Location |
Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}.
|
| Tissue Specificity |
Found in lymphocytes; preferentially expressed in CD8+ cells. {ECO:0000269|PubMed:11788997, ECO:0000269|PubMed:15274114}.
|