Gene Symbol | EFHD2 |
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Entrez Gene | 79180 |
Alt Symbol | SWS1 |
Species | Human |
Gene Type | protein-coding |
Description | EF-hand domain family, member D2 |
Other Description | EF hand domain containing 2|EF hand domain family, member D2|EF-hand domain-containing protein D2|swiprosin 1|swiprosin-1 |
Swissprots | Q5JYW9 Q96C19 |
Accessions | EAW51720 EAW51721 EAW51722 EAW51723 Q96C19 AI624416 BC003033 BC007233 AAH07233 BC013648 BC014923 AAH14923 BC023611 AAH23611 BC068473 AAH68473 BI753983 BM796344 XM_005246000 XP_005246057 XM_011542114 XP_011540416 NM_024329 NP_077305 |
Function | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
Subcellular Location | Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}. |
Tissue Specificity | Found in lymphocytes; preferentially expressed in CD8+ cells. {ECO:0000269|PubMed:11788997, ECO:0000269|PubMed:15274114}. |
Swiprosin-1 CRISPR/Cas9 KO Plasmid (h) - sc-404763 from Santa Cruz Biotechnology
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Swiprosin-1 HDR Plasmid (h) - sc-404763-HDR from Santa Cruz Biotechnology
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Swiprosin-1 Double Nickase Plasmid (h) - sc-404763-NIC from Santa Cruz Biotechnology
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Swiprosin-1 Double Nickase Plasmid (h2) - sc-404763-NIC-2 from Santa Cruz Biotechnology
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Swiprosin-1 CRISPR Activation Plasmid (h) - sc-404763-ACT from Santa Cruz Biotechnology
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Swiprosin-1 CRISPR Activation Plasmid (h2) - sc-404763-ACT-2 from Santa Cruz Biotechnology
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Swiprosin-1 Lentiviral Activation Particles (h) - sc-404763-LAC from Santa Cruz Biotechnology
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Swiprosin-1 Lentiviral Activation Particles (h2) - sc-404763-LAC-2 from Santa Cruz Biotechnology
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Swiprosin-1 siRNA (h) - sc-78656 from Santa Cruz Biotechnology
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Swiprosin-1 shRNA Plasmid (h) - sc-78656-SH from Santa Cruz Biotechnology
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Swiprosin-1 shRNA (h) Lentiviral Particles - sc-78656-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7693 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7693 from Sigma-Aldrich
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EFHD2 siRNA (Human) - CRJ2351 from Cohesion Biosciences
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EFHD2 RNAi - H00079180-R01 from Novus Biologicals
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EFHD2 - MBS828380 from MyBioSource
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shRNA set against Human EFHD2 (NM_024329.5) - SHH283609 from Creative biogene
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Human EFHD2 siRNA - orb272852 from Biorbyt
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EFHD2 shRNA Plasmid (Human) - CHJ2351 from Cohesion Biosciences
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EFHD2 miRNA 3'UTR clone - MiUTR3H-14715 from Creative biogene
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