| Gene Symbol |
MTNR1A
|
| Entrez Gene |
4543
|
| Alt Symbol |
MEL-1A-R, MT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melatonin receptor 1A
|
| Other Description |
mel1a receptor|melatonin receptor type 1A
|
| Swissprots |
A0AVC5 P48039 B0M0L2
|
| Accessions |
BAA85303 EAX04617 P48039 AF435588 AAL30809 BC074946 AAH74946 BC074947 AAH74947 BC113816 AAI13817 BC126297 AAI26298 BC126299 AAI26300 EU432127 ABY87926 HQ258378 ADR83132 U14108 AAB17720 XM_011532002 XP_011530304 NM_005958 NP_005949
|
| Function |
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
|
| Top Pathways |
Circadian entrainment, Neuroactive ligand-receptor interaction
|
![Western Blot: Melatonin Receptor 1A Overexpression Lysate (Adult Normal) [NBL1-13378] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Melatonin Receptor 1A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2490_Melatonin%2520Receptor%25201A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13378-img0002.jpg)