| Gene Symbol |
C1GALT1
|
| Entrez Gene |
56913
|
| Alt Symbol |
C1GALT, T-synthase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
|
| Other Description |
B3Gal-T8|core 1 O-glycan T-synthase|core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1|core 1 beta3-Gal-T1|core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
|
| Swissprots |
Q9BTU1 Q96QH4 Q9NS00
|
| Accessions |
AAQ96887 CAC43870 CCF77051 EAL24308 EAW93588 EAW93589 EAW93590 Q9NS00 AA443459 AF155582 AAF81981 AI400132 AI471988 AJ132443 CAC45046 AJ243256 CAC80435 AJ278960 CAC82373 AK023557 AK309328 BC003174 AAH03174 CB992707 CN360565 DA977378 DB106731 DB136152 XM_005249812 XP_005249869 XM_011515453 XP_011513755 XM_011515454 XP_011513756 XM_011515455 XP_011513757 XM_011515456 XP_011513758 NM_020156 NP_064541
|
| Function |
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in kidney, heart, placenta and liver. {ECO:0000269|PubMed:11677243}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|