Gene Symbol | C1GALT1 |
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Entrez Gene | 56913 |
Alt Symbol | C1GALT, T-synthase |
Species | Human |
Gene Type | protein-coding |
Description | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
Other Description | B3Gal-T8|core 1 O-glycan T-synthase|core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1|core 1 beta3-Gal-T1|core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
Swissprots | Q9BTU1 Q96QH4 Q9NS00 |
Accessions | AAQ96887 CAC43870 CCF77051 EAL24308 EAW93588 EAW93589 EAW93590 Q9NS00 AA443459 AF155582 AAF81981 AI400132 AI471988 AJ132443 CAC45046 AJ243256 CAC80435 AJ278960 CAC82373 AK023557 AK309328 BC003174 AAH03174 CB992707 CN360565 DA977378 DB106731 DB136152 XM_005249812 XP_005249869 XM_011515453 XP_011513755 XM_011515454 XP_011513756 XM_011515455 XP_011513757 XM_011515456 XP_011513758 NM_020156 NP_064541 |
Function | Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. Highly expressed in kidney, heart, placenta and liver. {ECO:0000269|PubMed:11677243}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
C1GALT1 CRISPR/Cas9 KO Plasmid (h) - sc-403509 from Santa Cruz Biotechnology
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C1GALT1 HDR Plasmid (h) - sc-403509-HDR from Santa Cruz Biotechnology
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C1GALT1 Double Nickase Plasmid (h) - sc-403509-NIC from Santa Cruz Biotechnology
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C1GALT1 Double Nickase Plasmid (h2) - sc-403509-NIC-2 from Santa Cruz Biotechnology
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C1GALT1 CRISPR Activation Plasmid (h) - sc-403509-ACT from Santa Cruz Biotechnology
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C1GALT1 CRISPR Activation Plasmid (h2) - sc-403509-ACT-2 from Santa Cruz Biotechnology
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C1GALT1 Lentiviral Activation Particles (h) - sc-403509-LAC from Santa Cruz Biotechnology
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C1GALT1 Lentiviral Activation Particles (h2) - sc-403509-LAC-2 from Santa Cruz Biotechnology
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C1GALT1 siRNA (h) - sc-72690 from Santa Cruz Biotechnology
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C1GALT1 shRNA Plasmid (h) - sc-72690-SH from Santa Cruz Biotechnology
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C1GALT1 shRNA (h) Lentiviral Particles - sc-72690-V from Santa Cruz Biotechnology
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C1GALT1 RNAi - H00056913-R01 from Novus Biologicals
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MISSION® esiRNA - EHU026231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4567 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4567 from Sigma-Aldrich
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C1GALT1 siRNA (Human) - CRJ1217 from Cohesion Biosciences
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C1GALT1 - MBS8217903 from MyBioSource
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shRNA set against Human C1galt1 (NM_020156.3) - SHH250282 from Creative biogene
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Human C1GALT1 siRNA - orb271718 from Biorbyt
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C1GALT1 shRNA Plasmid (Human) - CHJ1217 from Cohesion Biosciences
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C1GALT1 miRNA 3'UTR clone - MiUTR3H-11304 from Creative biogene
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