Gene Symbol | SIL1 |
---|---|
Entrez Gene | 64374 |
Alt Symbol | BAP, MSS, ULG5 |
Species | Human |
Gene Type | protein-coding |
Description | SIL1 nucleotide exchange factor |
Other Description | BiP-associated protein|SIL1 homolog, endoplasmic reticulum chaperone|nucleotide exchange factor SIL1 |
Swissprots | Q8N2L3 D3DQC2 Q9H173 |
Accessions | CAF86460 EAW62120 EAW62121 Q9H173 AF547994 AAN84477 AJ299442 CAC17773 AK074624 BAC11096 AK075177 BAC11452 AY358950 AAQ89309 BC011568 AAH11568 BI561751 CA415266 CB125000 CD369479 DQ059315 AAY89591 DQ173771 ABA60425 DQ173772 ABA60426 EU176328 ABW03779 EU176671 ABW03472 XM_011543570 XP_011541872 NM_001037633 NP_001032722 NM_022464 NP_071909 |
Function | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
Tissue Specificity | Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain. {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
Top Pathways | Protein processing in endoplasmic reticulum |