| Gene Symbol | SIL1 |
|---|---|
| Entrez Gene | 64374 |
| Alt Symbol | BAP, MSS, ULG5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SIL1 nucleotide exchange factor |
| Other Description | BiP-associated protein|SIL1 homolog, endoplasmic reticulum chaperone|nucleotide exchange factor SIL1 |
| Swissprots | Q8N2L3 D3DQC2 Q9H173 |
| Accessions | CAF86460 EAW62120 EAW62121 Q9H173 AF547994 AAN84477 AJ299442 CAC17773 AK074624 BAC11096 AK075177 BAC11452 AY358950 AAQ89309 BC011568 AAH11568 BI561751 CA415266 CB125000 CD369479 DQ059315 AAY89591 DQ173771 ABA60425 DQ173772 ABA60426 EU176328 ABW03779 EU176671 ABW03472 XM_011543570 XP_011541872 NM_001037633 NP_001032722 NM_022464 NP_071909 |
| Function | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
| Subcellular Location | Endoplasmic reticulum lumen {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
| Tissue Specificity | Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain. {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
| Top Pathways | Protein processing in endoplasmic reticulum |
SIL1 CRISPR/Cas9 KO Plasmid (h) - sc-413005 from Santa Cruz Biotechnology
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SIL1 HDR Plasmid (h) - sc-413005-HDR from Santa Cruz Biotechnology
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SIL1 Double Nickase Plasmid (h) - sc-413005-NIC from Santa Cruz Biotechnology
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SIL1 Double Nickase Plasmid (h2) - sc-413005-NIC-2 from Santa Cruz Biotechnology
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SIL1 CRISPR Activation Plasmid (h) - sc-413005-ACT from Santa Cruz Biotechnology
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SIL1 CRISPR Activation Plasmid (h2) - sc-413005-ACT-2 from Santa Cruz Biotechnology
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SIL1 Lentiviral Activation Particles (h) - sc-413005-LAC from Santa Cruz Biotechnology
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SIL1 Lentiviral Activation Particles (h2) - sc-413005-LAC-2 from Santa Cruz Biotechnology
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SIL1 siRNA (h) - sc-61553 from Santa Cruz Biotechnology
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SIL1 shRNA Plasmid (h) - sc-61553-SH from Santa Cruz Biotechnology
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SIL1 shRNA (h) Lentiviral Particles - sc-61553-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU048311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19344 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19344 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03160 from Sigma-Aldrich
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SIL1 siRNA (Human) - CRJ1994 from Cohesion Biosciences
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SIL1 - MBS8230199 from MyBioSource
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shRNA set against Human SIL1 (NM_022464.4) - SHH407572 from Creative biogene
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shRNA set against Human SIL1(NM_001037633.1) - SHR225686 from Creative biogene
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shRNA set against Human SIL1(NM_022464.4) - SHR225698 from Creative biogene
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shRNA set against Human SIL1(NM_001037633.1) - SHR225699 from Creative biogene
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shRNA set against Human SIL1(NM_022464.4) - SHR225700 from Creative biogene
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shRNA set against Human SIL1(NM_001037633.1) - SHR225701 from Creative biogene
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shRNA set against Human SIL1(NM_022464.4) - SHR225702 from Creative biogene
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shRNA set against Human SIL1(NM_001037633.1) - SHR225703 from Creative biogene
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