| Gene Symbol |
SH3PXD2A
|
| Entrez Gene |
9644
|
| Alt Symbol |
FISH, SH3MD1, TKS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3 and PX domains 2A
|
| Other Description |
SH3 and PX domain-containing protein 2A|SH3 multiple domains 1|adapter protein TKS5|adaptor protein TKS5|five SH3 domain-containing protein|tyrosine kinase substrate with five SH3 domains
|
| Swissprots |
Q5TCZ1 D3DR98 Q5TDQ8 Q5TCZ2 O43302
|
| Accessions |
EAW49622 EAW49623 EAW49624 EAW49625 Q5TCZ1 AB007878 BAA24848 AK025783 AK056469 BAG51723 AK096575 AK123570 AK294454 BAH11772 AK294736 BAH11864 AK295314 BAH12031 AK295660 BAH12146 AK302015 BAH13608 AK304828 BAH14262 AK315983 BAH14354 AL833070 CAD89969 BC146309 AAI46310 BC156572 AAI56573 BX647371 CN307901 XM_005270294 XP_005270351 XM_005270295 XP_005270352 XM_005270297 XP_005270354 XM_005270298 XP_005270355 XM_006718079 XP_006718142 XM_006718080 XP_006718143 XM_011540385 XP_011538687 XM_011540386 XP_011538688 XM_011540387 XP_011538689 NM_014631 NP_055446
|
| Function |
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
|
| Subcellular Location |
Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
|
| Tissue Specificity |
Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.
|