SH3PXD2A

Gene Symbol SH3PXD2A
Entrez Gene 9644
Alt Symbol FISH, SH3MD1, TKS5
Species Human
Gene Type protein-coding
Description SH3 and PX domains 2A
Other Description SH3 and PX domain-containing protein 2A|SH3 multiple domains 1|adapter protein TKS5|adaptor protein TKS5|five SH3 domain-containing protein|tyrosine kinase substrate with five SH3 domains
Swissprots Q5TCZ1 D3DR98 Q5TDQ8 Q5TCZ2 O43302
Accessions EAW49622 EAW49623 EAW49624 EAW49625 Q5TCZ1 AB007878 BAA24848 AK025783 AK056469 BAG51723 AK096575 AK123570 AK294454 BAH11772 AK294736 BAH11864 AK295314 BAH12031 AK295660 BAH12146 AK302015 BAH13608 AK304828 BAH14262 AK315983 BAH14354 AL833070 CAD89969 BC146309 AAI46310 BC156572 AAI56573 BX647371 CN307901 XM_005270294 XP_005270351 XM_005270295 XP_005270352 XM_005270297 XP_005270354 XM_005270298 XP_005270355 XM_006718079 XP_006718142 XM_006718080 XP_006718143 XM_011540385 XP_011538687 XM_011540386 XP_011538688 XM_011540387 XP_011538689 NM_014631 NP_055446
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
Subcellular Location Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Tissue Specificity Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.

SH3PXD2A / TKS5 Antibody Blocking Peptide - LS-E4283 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SH3PXD2A / TKS5 Blocking Peptide - LS-E27351 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SH3PXD2A-Antibody-N-term-Blocking-Peptide - BP16560a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human SH3 and PX domain-containing protein 2A(SH3PXD2A) ,partial - CSB-YP735983HU CSB-EP735983HU CSB-BP735983HU CSB-MP735983HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

SH3PXD2A Protein - NBP1-90455PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

SH3PXD2A Recombinant Protein Antigen - NBP1-90454PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SH3PXD2A Peptide, Human - M34GP14183H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

SH3 and PX domain-containing protein 2A (SH3PXD2A), partial, Recombinant Protein - MBS1325334 from MyBioSource

Category Protein
Prices $475.00, $635.00, $650.00, $700.00, $810.00, $880.00, $985.00, $995.00, $1,015.00, $1,045.00, $1,475.00, $1,500.00, $1,600.00, $1,980.00
Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Yeast), 500 µg (E-Coli), 50 µg (Baculovirus), 200 µg (Yeast), 1 mg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Human SH3PXD2A Protein (902-986 aa), His-Myc-tagged - SH3PXD2A-2587H from Creative Biomart

Category Protein
Source E. coli
Species Human
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