SH3PXD2A

Gene Symbol SH3PXD2A
Entrez Gene 9644
Alt Symbol FISH, SH3MD1, TKS5
Species Human
Gene Type protein-coding
Description SH3 and PX domains 2A
Other Description SH3 and PX domain-containing protein 2A|SH3 multiple domains 1|adapter protein TKS5|adaptor protein TKS5|five SH3 domain-containing protein|tyrosine kinase substrate with five SH3 domains
Swissprots Q5TCZ1 D3DR98 Q5TDQ8 Q5TCZ2 O43302
Accessions EAW49622 EAW49623 EAW49624 EAW49625 Q5TCZ1 AB007878 BAA24848 AK025783 AK056469 BAG51723 AK096575 AK123570 AK294454 BAH11772 AK294736 BAH11864 AK295314 BAH12031 AK295660 BAH12146 AK302015 BAH13608 AK304828 BAH14262 AK315983 BAH14354 AL833070 CAD89969 BC146309 AAI46310 BC156572 AAI56573 BX647371 CN307901 XM_005270294 XP_005270351 XM_005270295 XP_005270352 XM_005270297 XP_005270354 XM_005270298 XP_005270355 XM_006718079 XP_006718142 XM_006718080 XP_006718143 XM_011540385 XP_011538687 XM_011540386 XP_011538688 XM_011540387 XP_011538689 NM_014631 NP_055446
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
Subcellular Location Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Tissue Specificity Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.

fish (G-7) - sc-376211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
fish (G-7): sc-376211. Western blot analysis of fish expression in K-562 whole cell lysate.

fish (M-20) - sc-9945 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
fish (M-20): sc-9945. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells.

fish (M-300) - sc-30122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
fish (M-300): sc-30122. Western blot analysis of fish expression in K-562 whole cell lysate.

Anti-FISH antibody - ab118575 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118575 at a concentration of 7.5 µg/ml.

Anti-FISH antibody - ab129705 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FISH antibody (ab129705) at 1/100 dilution + HeLa cell line lysate at 35 µg

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, APC) - LS-C269294 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, AP) - LS-C269293 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, Biotin) - LS-C269295 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, Azide-free, HRP) - LS-C269297 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, PE) - LS-C269298 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250, FITC) - LS-C269296 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa221-250) - LS-C330123 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2A / TKS5 Antibody (aa222-250) - LS-C169066 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SH3PXD2A Antibody western blot of HeLa cell line lysates (35 ug/lane). The SH3PXD2A antibody detected the SH3PXD2A protein (arrow).

Anti-SH3PXD2A / TKS5 Antibody (aa1033-1046) IHC-plus™ - LS-B5142 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SH3PXD2A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5142 concentration 3.75 ug/ml.

SH3PXD2A Antibody - NBP1-90454 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH3PXD2A Antibody [NBP1-90454] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

SH3PXD2A Antibody - NBP1-90455 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SH3PXD2A Antibody [NBP1-90455] - Staining of human placenta shows strong membranous positivity in trophoblastic cells.

SH3PXD2A Antibody - H00009644-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

FISH Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11645R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11645R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11645R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11645R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, Cy3 Conjugated - bs-11645R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, Cy5 Conjugated - bs-11645R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, Cy5.5 Conjugated - bs-11645R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FISH Polyclonal Antibody, Cy7 Conjugated - bs-11645R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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