| Gene Symbol |
PNRC2
|
| Entrez Gene |
55629
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proline-rich nuclear receptor coactivator 2
|
| Other Description |
-
|
| Swissprots |
B4DU72 Q9NPJ4
|
| Accessions |
EAW95101 EAW95102 Q9NPJ4 AF151042 AAF36128 AF374386 AAK54613 AK000319 BAA91082 AK024774 AK300522 BAG62234 AK311305 BC001959 AAH01959 BC068475 BC078177 AAH78177 BC085018 AAH85018 DA043474 NM_017761 NP_060231
|
| Function |
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. {ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19150429}. Cytoplasm, P-body {ECO:0000269|PubMed:19150429}.
|
| Tissue Specificity |
Expressed in heart, lung, muscle and brain. {ECO:0000269|PubMed:11574675}.
|