Gene Symbol | PNRC2 |
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Entrez Gene | 55629 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | proline-rich nuclear receptor coactivator 2 |
Other Description | - |
Swissprots | B4DU72 Q9NPJ4 |
Accessions | EAW95101 EAW95102 Q9NPJ4 AF151042 AAF36128 AF374386 AAK54613 AK000319 BAA91082 AK024774 AK300522 BAG62234 AK311305 BC001959 AAH01959 BC068475 BC078177 AAH78177 BC085018 AAH85018 DA043474 NM_017761 NP_060231 |
Function | Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. {ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19150429}. Cytoplasm, P-body {ECO:0000269|PubMed:19150429}. |
Tissue Specificity | Expressed in heart, lung, muscle and brain. {ECO:0000269|PubMed:11574675}. |
PNRC2 CRISPR/Cas9 KO Plasmid (h) - sc-416553 from Santa Cruz Biotechnology
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PNRC2 HDR Plasmid (h) - sc-416553-HDR from Santa Cruz Biotechnology
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PNRC2 Double Nickase Plasmid (h) - sc-416553-NIC from Santa Cruz Biotechnology
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PNRC2 Double Nickase Plasmid (h2) - sc-416553-NIC-2 from Santa Cruz Biotechnology
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PNRC2 CRISPR Activation Plasmid (h) - sc-416553-ACT from Santa Cruz Biotechnology
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PNRC2 CRISPR Activation Plasmid (h2) - sc-416553-ACT-2 from Santa Cruz Biotechnology
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PNRC2 Lentiviral Activation Particles (h) - sc-416553-LAC from Santa Cruz Biotechnology
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PNRC2 Lentiviral Activation Particles (h2) - sc-416553-LAC-2 from Santa Cruz Biotechnology
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PNRC2 siRNA (h) - sc-78752 from Santa Cruz Biotechnology
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PNRC2 shRNA Plasmid (h) - sc-78752-SH from Santa Cruz Biotechnology
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PNRC2 shRNA (h) Lentiviral Particles - sc-78752-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17073 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17073 from Sigma-Aldrich
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PNRC2 siRNA (Human) - CRJ0788 from Cohesion Biosciences
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Human PNRC2 siRNA - orb271289 from Biorbyt
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PNRC2 shRNA Plasmid (Human) - CHJ0788 from Cohesion Biosciences
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PNRC2 miRNA 3'UTR clone - MiUTR3H-12195 from Creative biogene
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