PARP1

Gene Symbol	PARP1
Entrez Gene	142
Alt Symbol	ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Species	Human
Gene Type	protein-coding
Description	poly (ADP-ribose) polymerase 1
Other Description	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)|ADP-ribosyltransferase NAD(+)|ADP-ribosyltransferase diphtheria toxin-like 1|NAD(+) ADP-ribosyltransferase 1|poly (ADP-ribose) polymerase family, member 1|poly [ADP-ribose] polymerase 1|poly(ADP-ribose) polymerase|poly(ADP-ribose) synthetase|poly(ADP-ribosyl)transferase|poly[ADP-ribose] synthase 1
Swissprots	B1ANJ4 P09874 Q8IUZ9
Accessions	AAA51663 AAA60000 AAM75364 CAA34663 CAA39606 CBX74363 EAW69783 EAW69784 EAW69785 P09874 AF401218 AAL02174 AK125650 AK225654 AK303340 BAG64403 AK312339 BAG35260 BC008660 BC014206 AAH14206 BC018620 AAH18620 BC021045 BC037545 AAH37545 DB097441 DQ891636 ABM82562 DQ894826 ABM85752 J03473 AAB59447 M17081 AAA51599 M18112 AAA60137 M32721 AAA60155 NM_001618 NP_001609
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:17177976, E
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PARP (mutated E988 K) full length protein - ab157027 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source Baculovirus infected Sf21 cells Species Human

Active human PARP full length protein - ab79663 from Abcam Category Protein Prices $492.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PARP full length protein - ab123834 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source Baculovirus Species Human

Active human PARP full length protein - ab157281 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source Baculovirus infected Sf21 cells Species Human

Active human PARP full length protein - ab157046 from Abcam Category Protein Prices $528.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human PARP full length protein - ab75605 from Abcam Category Protein Source Baculovirus Species Human

Human PARP peptide - ab45360 from Abcam Category Peptide

Human PARP protein fragment - ab157286 from Abcam Category Protein Source Baculovirus infected Sf21 cells Species Human

Human PARP protein fragment - ab157069 from Abcam Category Protein Source E. coli Species Human

Human PARP protein fragment - ab93465 from Abcam Category Protein Source E. coli Species Human

PARP1 Antibody Blocking Peptide - LS-E2344 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7537 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7539 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7540 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7541 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7542 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E7543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E11941 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP1 Antibody Blocking Peptide - LS-E8216 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP Partial Recombinant Protein - H00000142-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PARP Protein - NBP1-37088 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

PARP Protein - NBP1-99635 from Novus Biologicals Category Protein Prices $499.00 Sizes 50 µg Species Human

PARP Peptide - P2032 from Novus Biologicals Category Peptide Species Human

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