PARP1

Gene Symbol	PARP1
Entrez Gene	142
Alt Symbol	ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Species	Human
Gene Type	protein-coding
Description	poly (ADP-ribose) polymerase 1
Other Description	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)|ADP-ribosyltransferase NAD(+)|ADP-ribosyltransferase diphtheria toxin-like 1|NAD(+) ADP-ribosyltransferase 1|poly (ADP-ribose) polymerase family, member 1|poly [ADP-ribose] polymerase 1|poly(ADP-ribose) polymerase|poly(ADP-ribose) synthetase|poly(ADP-ribosyl)transferase|poly[ADP-ribose] synthase 1
Swissprots	B1ANJ4 P09874 Q8IUZ9
Accessions	AAA51663 AAA60000 AAM75364 CAA34663 CAA39606 CBX74363 EAW69783 EAW69784 EAW69785 P09874 AF401218 AAL02174 AK125650 AK225654 AK303340 BAG64403 AK312339 BAG35260 BC008660 BC014206 AAH14206 BC018620 AAH18620 BC021045 BC037545 AAH37545 DB097441 DQ891636 ABM82562 DQ894826 ABM85752 J03473 AAB59447 M17081 AAA51599 M18112 AAA60137 M32721 AAA60155 NM_001618 NP_001609
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:17177976, E
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PARP siRNA I - 6304 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PARP siRNA II - 6305 from Cell Signaling Technology Category siRNA

PARP-1 CRISPR/Cas9 KO Plasmid (h) - sc-400046 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 HDR Plasmid (h) - sc-400046-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 Double Nickase Plasmid (h) - sc-400046-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 Double Nickase Plasmid (h2) - sc-400046-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 CRISPR Activation Plasmid (h) - sc-400046-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 CRISPR Activation Plasmid (h2) - sc-400046-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 Lentiviral Activation Particles (h) - sc-400046-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 Lentiviral Activation Particles (h2) - sc-400046-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PARP-1 siRNA (h) - sc-29437 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PARP-1 shRNA Plasmid (h) - sc-29437-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PARP-1 shRNA (h) Lentiviral Particles - sc-29437-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PARP RNAi - H00000142-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU050101 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1116 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1283 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1116 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05985 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05985

PARP1 siRNA (Human) - CRH0099 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PARP1 (NM_001618.3) - SHH370812 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PARP1(NM_001618.3) - SHR088494 from Creative biogene Category siRNA Species Reactivities Human

Human PARP1 siRNA - orb260601 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PARP1 shRNA Plasmid (Human) - CHH0099 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PARP1 miRNA 3'UTR clone - MiUTR1H-07517 from Creative biogene Species Reactivities Human

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