| Gene Symbol |
UCP3
|
| Entrez Gene |
7352
|
| Alt Symbol |
SLC25A9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
uncoupling protein 3 (mitochondrial, proton carrier)
|
| Other Description |
mitochondrial uncoupling protein 3|solute carrier family 25 member 9
|
| Swissprots |
O60475 Q96HL3 P55916
|
| Accessions |
AAC18822 AAC51785 AAG02284 EAW74925 EAW74926 EAW74927 P55916 AF001787 AAC51369 AF011449 AAC51767 AK092685 BAG52595 AK290630 BAF83319 AK291889 BAF84578 AK309873 AW295096 BC008392 AAH08392 BU618868 DA876282 U82818 AAC51356 U84763 AAC51367 NM_003356 NP_003347 NM_022803 NP_073714
|
| Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269|PubMed:9196039}.
|
![Western Blot: UCP3 Overexpression Lysate (Adult Normal) [NBL1-17583] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UCP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3472_UCP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17583-img0002.jpg)